Contents

Reducing creatine kinase-MB levels following oxytocin administration during ischemia-reperfusion periods in isolated rat heart
Khansari M, Imani A, Faghihi M, Aali Anvari M, Moghimian M, Sadeghipour Roodsari H.R.

The effects of isosorbide dinitrate on in vitro proliferation of WEHI-164 cells and peripheral blood mononuclear cells
Hajighasemi F, Resvan Madani F.Z.

Protective effect of dendrosomal curcumin combination on colon cancer in rat
Sarbolouki M.N, Alizadeh A.M, Khaniki M, Azizian S, Mohaghgheghi M.A.

Inducing maturation of monocyte-derived dendritic cells on human epithelial cell feeder layer
Ganji Bakhsh M, Nejati V, Asadi M, Delirezh N, Farokhi F.

Effects of fibroblasts conditioned media on differentiation of programmable cells of monocytic origin to insulin-producing cells
Chapari H, Farokhi F, Delirezh N, Javadi Sh, Tanhaye Kalate Sabz F.

The effect of oral ascorbic acid pretreatment on feeding changes following injection in nucleus accumbens shell in adult male rats
Salari S, Abbasnejad M, Badreh F, Esmaeili Mahani S.

Therapeutic effects of all-trans retinoic acid on experimental autoimmune encephalomyelitis and its role in T-helper lymphocyte responses
Abtahi Froushani S.M, Delirezh N, Hobbenaghi R, Mosayebi Gh.

Reduction of left ventricular hypertrophy by Sirolimus in kidney transplant recipients:  a nonrandomized clinical trial
Sedghipour M, Tabatabaei S.A.H, Sadadi F, Kamal Hedayat D, Nikdoost F, Sate H, Ghorbani Yekta B.

Dabigatran etexilate, a novel oral direct thrombin inhibitor, for preventing thromboembolic events after knee replacement arthroplasty
Moghtadaee M, Shahhoseini Gh.R, Farahini H, Yegane A, Rajabpour S.

Midazolam versus ketamine in the management of emergence agitation in children undergoing lower abdominal and limb surgeries
Khalili Gh.R, Sajedi P, Danesh H.

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 730-736

Gholam Reza Khalili M.D.1
Parvin Sajedi M.D.1*
Hamideh Danesh M.D.2

1- Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

* Corresponding author: Dept. of Anesthesia and Critical Care, AL -Zahra Medical Center, Sofeh St., Isfahan, Iran.
Tel: +98-311-7769721
E-mail: sajedi@med.mui.ac.ir

Received: January 17, 2011    Accepted: November 27, 2011

Background: Emergence agitation (EA) is a post-anesthetic problem which interferes with a child’s recovery and presents a challenge in terms of assessment and management. In this study, we compared the effects of midazolam and ketamine as premedication in the management of EA in children aged 1-6 years. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 725-729

Mehdi Moghtadaee M.D.
Gholamreza Shahhoseini M.D.
Hosein Farahini M.D.
Ali Yegane M.D.
Saeed Rajabpour M.D.*

Department of Orthopedic Surgery, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Dept. of Orthopedic Surgery, Rasoul Akram Hospital, Nyayesh St., Sattarkhan Ave., Tehran, Iran.
Tel: +98-21-66507059
E-mail: saeed_rajabpour@yahoo.com

Received: July 12, 2011    Accepted: November 29, 2011

Background: Dabigatran etexilate is one of the few direct thrombin inhibitors with anti-coagulant activities and the following distinctive features: taken orally, no need to closely monitor for complications, and no need for regular dose adjustments. Relying on the above mentioned valuable advantages, dabigatran etexilate can be considered as a premier choice for the prevention of venous thromboembolism after knee replacement arthroplasty. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 718-724

Mohsen Sedghipour M.D.1*
Seyyed Abdol Hossein Tabatabaei M.D.2
Fereshteh Sadadi M.D.3
Darioush Kamal Hedayat M.D.2
Farahnaz Nikdoost M.D.2
Hossein Sate M.D.1
Batool Ghorbani Yekta Ph.D.4

1- Department of Heart, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Heart, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Nephrology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Physiology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

* Corresponding author: Dept. of Cardiology, Shariati Hospital, Jalal Al Ahmad High way, Karegar Ave., Keshavarz Blvd., Tehran, Iran.
Tel: +98-21-61192647
E-mail: mohsen.sedghipour@yahoo.com

Received: July 29, 2011    Accepted: November 21, 2011

Background: Persistence of left ventricular hypertrophy (LVH) in renal transplant recipients is associated with unfavorable outcomes. Calcineurin-inhibitor (CNI) nephrotoxicity is a major cause of morbidity and mortality after kidney transplantation. In this study we compared sirolimus (SRL) with calcineurin-inhibitor as primary immunosuppressants for the attenuation of left ventricular hypertrophy in renal transplantation recipients. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 710-717

Seyyed Meysam Abtahi Froushani D.V.M.1*
Norouz Delirezh Ph.D.1
Rahim Hobbenaghi D.V.SC2
Ghasem Mosayebi Ph.D.3

1- Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
2- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
3- Department of Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

* Corresponding author: Dept. of Microbiology, Veterinary Faculty, Urmia University, Sero Road, Urmia, Iran.
Tel: +98-913-3000470
E-mail: meysam.abtahi@yahoo.com

Received: November 02, 2011    Accepted: November 29, 2011

Background: Recent studies have demonstrated an essential role for IL-17 in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). Furthermore, it has been shown that FoxP3+Treg cells play an important role in the suppression of autoinflammatory reactions. Although, previous studies have determined the immunomodulatory potentials of all-trans-retinoic acid (ATRA), but these immunomodulations have been mostly justified by alteration in Th1/Th2 cytokines. The present study was carried out to investigate the therapeutic effects of ATRA on EAE and its effects on T-helper cells responses. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 703-709

Sahar Salari M.Sc.
Mehdi Abbasnejad Ph.D.*
Firuzeh Badreh M.Sc.
Saeed Esmaeili Mahani Ph.D.

Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.

* Corresponding author: Dept. of Biology, Faculty of Science, Shahid Bahonar University, Kerman, Iran.
Tel: +98-913-1409009
E-mail: mabbas@mail.uk.ac.ir

Received: October 02, 2011    Accepted: November 28, 2011

Background: Ascorbic acid (AA) is not synthesized in the brain but it is actively transported through blood-brain barrier by SVCT2 cotransporter and it is stored in high concentrations with heterogeneous distribution in areas such as nucleus accumbens shell (AcbSh) in the mammalian brain. Previous studies have shown that Ascorbic acid injection into AcbSh decreases feeding; therefore, in the present study we evaluated the effects of oral Ascorbic acid pretreatment on changes in feeding upon its injection in AcbSh in adult male rats. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 695-702

Havva Chapari M.Sc.1*
Farah Farokhi Ph.D.1
Nowruz Delirezh Ph.D.2
Shahram Javadi Ph.D.3
Fatemeh Tanhaye Kalate Sabz M.Sc.1

1- Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.
2- Department of Immunology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
3- Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

* Corresponding author: Dept. of Biology, Faculty of Science, Urmia University, Urmia, Iran. Postal Code: 5715915199
Tel: +98-914-4030280
E-mail: havva.ch@gmail.com

Received: April 23, 2011    Accepted: May 25, 2011

Background: The characteristic of stem cells in self renewal and differentiation to different types of cells has stimulated the interests for using stem cells as a starting material for generating insulin secreting cells. We’ve evaluated the differentiation potential of Programmable cells of monocytic origin (PCMOs) into insulin producing cells effected from the growth factors and fibroblasts conditioned media (FCM). (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 686-694

Meysam Ganji Bakhsh M.Sc.1*
Vahid Nejati Ph.D.1
Masoumeh Asadi M.Sc.1
Nowruz Delirezh Ph.D.2
Farah Farokhi Ph.D.1

1- Department of Biology and Embryology, Faculty of Science, Urmia University, Urmia, Iran.
2- Department of Immunology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

* Corresponding author: Dept. of Biology, Faculty of Science, Urmia University, P.O. Box 5715915199, Nazlou Road, Urmia, Iran.
Tel: +98-935-9689985
E-mail: meysam_ganjy@yahoo.com

Received: February 22, 2011    Accepted: May 07, 2011

Background: Nowadays, dendritic cells (DCs) have a special place in cancer treatment strategies and they have been used for tumor immunotherapy as they can induce immune response against tumor cells. Researchers have been trying to generate efficient dendritic cells in vitro; therefore, this research was done to generate them for use in research and tumor immunotherapy. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 678-685

Mohammad Nabi Sarbolouki Ph.D.1
Ali Mohammad Alizadeh Ph.D.2*
Mahmod Khaniki M.D.3
Saleh Azizian M.D.2
Mohammad Ali Mohaghgheghi M.D.2

1- Zistmavad Research Center, Tehran University, Tehran, Iran.
2- Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Cancer Research Center, Cancer Institute of Iran, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran.
Tel: +98-21-61192501
E-mail: aalizadeh@razi.tums.ac.ir

Received: October 04, 2011    Accepted: November 02, 2011

Background: Cancer is a multistep process that develops very rapidly after its onset. Previous studies have confirmed antitumor effects of curcumin (1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; diferuloylmethane) that can potentially prevent colon cancer development with low side-effects. Different methods have been performed to increase the efficiency and effectiveness of curcumin among which dendrosome, a nanoparticle created by Sarbolouki et al. was used in this study. The present study was undertaken to evaluate the effects of dendrosomal curcumin on rat colon cancer. (more…)

Original Article

TUMJ; Vol. 69, No. 11, February 2012: 671-677

Fatemeh Hajighasemi Ph.D.*
Fatemeh Zahra Resvan Madani M.D.

Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran.

* Corresponding author: Dept. of Immunology, Faculty of Medicine, Shahed University, Shahid Abdollahzadeh St., Keshavarz Blvd., 1415635111
Tel: +98-21-88964792
E-mail: resoome@yahoo.com

Received: October 15, 2011    Accepted: November 12, 2011

Background: Isosorbide dinitrate has been broadly used in the treatment of various ischemic heart diseases. Isosorbide is a nitric oxide donor which increases blood flow to tumors through vasodilatation and consequently accelerates the access of chemo-drugs to them. Furthermore, this drug has inhibitory effects on angiogenesis, tumor growth and metastasis in vivo. Moreover, its ant-inflammatory effects have also been reported. In the present study we evaluated the effects of isosorbide on the proliferative activity of fibrosarcoma WEHI-164 cell line and peripheral blood mononuclear cells (PBMCs). (more…)