Fever and neutropenia due to cytomegalovirus infection in a breast cancer patient under chemotherapy: a case report

Received: May 08, 2010    Accepted: May 23, 2010

Zahra Ahmadinejad M.D.*
Ali reza Soleimani M.D.

Department of Infectious Diseases, Imam Khomeini Grand Hospital Complex

Tehran University of Medical Sciences

Background: Fever in neutropenic patients is a medical emergency which may happen in patients undergoing chemotherapy. The definition of neutropenia varies from institution to institution but is usually defined as an absolute neutrophil count (ANC)    < 500 cells/ml or < 1,000 cells/ml with a predicted nadir of < 500 cells/ml. Bacterial and fungal infections are the most important in neutropenic patients. Viral infections with agents such as herpes simplex virus and cytomegalovirus are common but less than other pathogens. (more…)

Molecular epidemiology of human respiratory syncytial virus in Iranian children less than 5 years in 2007: a study on 72 cases

Received: March 13, 2010    Accepted: May 29, 2010

Ebrahim Faghihloo M.Sc.1
Farhad Rezaie Ph.D. Student1
Vahid Salimi Ph.D. Student1
Maryam Naseri M.Sc.1
Setare Mamishi M.D.2
Mahmood Mahmoodi Ph.D.3
Talat Mokhtari-Azad Ph.D.1*

1- Department of Virology, School of Public Health
2- Department of Pediatrics, Infectious Disease Research Center, Children’s Medical Center
3- Department of Biostatic and Epidemiology, School of Public Health

Tehran University of Medical Sciences

Background: Human respiratory syncytial virus (HRSV) is the most important viral agent of acute lower respiratory tract disease in infants and young children worldwide. This virus is responsible for 50% brochiolitis and 25% pneumonia in infants. There are limited data of molecular epidemiology of HRSV from developing countries. This is the report on the molecular epidemiology of human respiratory syncytial virus in Iran. (more…)

Pulmonary Hydatid cyst: analysis of 1024 cases

Received: December 02, 2009    Accepted: March 10, 2010

Reza Bagheri M.D.1,3*
Seyyed Ziaollah Haghi M.D.1
Maahnaz Amini M.D.2
Asieh Sadat Fattahi M.D.3

1- Department of Thoracic Surgery
2- Department of Medicine
3- Endoscopic & Minimally Invasive Research Center

Mashhad University of Medical Sciences

Background: Pulmonary hydatic cyst is a common parasitic disease and health care problem in developing countries. In our study we assessed treatment outcomes of pulmonary hydatic cyst in our area.

Methods: All patients presenting to Ghaem, Omid and Mehr hospitals of Mashhad- Iran since 1981 to 2008 with pulmonary hydatic cyst were enrolled in this study and demographic data, location and number of cysts, diagnostic methods, type of operations, out comes and rate of recurrence were statistically analyzed. (more…)

The relationship between cardiovascular risk factors and the site and extent of coronary artery stenosis according to angiographic findings

Received: February 09, 2010    Accepted: April 07, 2010

Amir Farhang Zand Parsa M.D1*
Hamid Ziai M.D.1
Babak Fallahi M.D.2

1- Department of Cardiology, Imam Khomeini Medical Center
2- Department of Nuclear Medicine, Shariati Hospital

Tehran University of Medical Sciences

Background: Coronary Artery Disease (CAD) is one of the leading causes of mortality and morbidity all over the world. One of the most important predictors of outcome of patients with coronary aterey disease is the site of stenosis i.e. Proximal versus nonproximal stenosis. This study designed to evaluate the relationship between CAD risk factors and site of stenosis. (more…)

Induction of labor in term pregnancy: Sublingual versus vaginal misoprostol

Received: March 06, 2010    Accepted: April 26, 2010

Aboutaleb Beigi M.D.1*
Seyyedeh-Mitra Kazemipour M.D.1
Hoda Tabarestani M.D.2

1- Department of Gynecology and Obstetrics, Arash Hospital
2- Department of Gynecology and Obstetrics

Tehran University of Medical Sciences

Background: Induction of labor implies stimulation of contractions before the spontaneous onset of labor and is indicated when have benefits to eighter mother or fetus. Uterine contractions and an appropriate cervix are two important factors in labor and are contributed to good outcomes. Nowadays, there are many therapeutic modalities for it such as misoprostol. Both vaginal and oral misoprostol may be used for eighter cervical ripening or labor induction. The tablets are stable at room temperature. Regarding the issue importance and lack of similar studies in Iran, this study was conducted to compare the efficacy of sublingual and vaginal misoprostol for labor induction. (more…)

Repair of inguinal hernia: a comparison between extraperitoneal laparoscopy and Lichtenstein open surgery

Received: March 10, 2010    Accepted: May 19, 2010

Alireza Tavassoli M.D.1*
Mohamad Javad Ghamari M.D.1
Habibollah Esmaily Ph.D.2

1- Endoscopic and Minimally Invasive Research Center, Department of General Surgery
2- Department of Biostatistics and Epidemiology

Mashhad University of Medical Sciences

Background: The inguinal hernia is a common disorder in general surgery. Different methods have been described for repair of these hernias. In modern methods, synthetic mesh is used to cover the wall defect and the most known method is Lichtenstein surgical repair. The laparoscopic totally extra peritoneal procedure (TEP) is a newer technique of repairing hernia. The aim of this study is to compare the outcomes of totally extraperitoneal laparoscopic inguinal hernia repair versus Lichtenstein open repair in patients with inguinal hernia. (more…)

Radiosurgery for skull base meningiomas: a study on 230 cases in Iranian Gamma Knife Center

Received: April 21, 2010    Accepted: May 24, 2010

Mohammad Ali Bitaraf M.D.1*
Mazyar Azar M.D.2
Seyed Mojtaba Miri M.D.1
Abdolreza Sheikhrezai M.D.1
Mazdak Alikhani M.D.2
Mahmud Allahverdi M.D.2
Ahmad Sharif Tabrizi M.D.2
Ali Tayebi Meybodi M.D.1

1- Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences
2- Iranian Gamma-Knife Center

Background: Meningiomas are among the most common tumors of the brain. Skull base meningiomas comprise s major part of brain meningiomas. They are difficult to treat because of proximity to major vital neuro-vascular structures which makes their surgical resection hazardous and fraught with a high rate of complications. Radiosurgery is considered as an alternative efficient way to treat them, which targets the tumor and its supplying vasculature. The standard treatment consists of tumor eradication and its supplying vessels through homogeneous dose of 201 rays of cobalt 60 source. (more…)

An optimized mixture of kiwifruit actinidin and trypsin for isolation and culture of endothelial cells from rat aorta

Received: January 23, 2010    Accepted: April 06, 2010

Mahvash Hesari M.Sc.1
Kamran Mansouri M.Sc.2
Ali Mostafaie Ph.D.3*
Ali Bidmeshkipour Ph.D.4

1- M. Sc. of Cellular and Molecular Biology
2- M. Sc. of Hematology
3- Department of Immunology

Medical Biology Research Center, Kermanshah University of Medical Sciences.

4- Department of Biology, Faculty of Sciences, Razi University.

Background: Proteolytic enzymes, especially collagenases, are used for digestion of extracellular matrix, cell isolation and primary culture. Because of the problems in purification and low amount of collagenases in bacterial or animal sources, it is important to find new sources of the enzymes. So, in the present study actinidin, a plentiful protein in kiwifruit was purified and a mixture of actinidin and trypsin was applied to isolate rat aortic endothelial cells. (more…)

The design of a “specific- IgE ELISA assay kit” for major cow’s milk allergens

Received: April 10, 2010    Accepted: May 19, 2010

Gholam Ali Kardar M.Sc.1
Zahra Pourpak M.D., Ph.D.2*

1- Ph.D. Student in Molecular Genetic
2- Department of Immunology

Immunology, Asthma & Allergy Research Institute, Children’s Medical Center, Tehran University of Medical Sciences

Background: The hypersensitivity to cow’s milk allergens is the most common allergies in children at the first year of life. The specific IgE evaluation is one of the important methods in diagnosis of allergic disease. The aim of this study was development of a sensitive and credible procedure for detection of cow’s milk allergens specific IgE. (more…)

The effects of radiation leakage of microwave oven on body weight, cortisol, thyroid hormones and lipid profile in immature mice

Received: December 30, 2009    Accepted: May 05, 2010

Gholamali Jelodar Ph.D.1*
Mohammad Beyzaee DVM2

1- Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2- Veterinarian

Background: High-frequency electromagnetic field (EMF) is generated by different sources such as radar installations, radio and television transmitters, medical microwave diathermy device and domestic use of microwave ovens. Radiation leakage of microwave oven may be harmful for users. Kids who are residing near their mothers may expose to electromagnetic field. This study was carried out to evaluate the effect of radiation leakage of microwave oven on body weight, cortisol, thyroid hormones and plasma lipid profile. (more…)

Clear cell adenocarcinoma of the cevix  without in utero diethylstilbestrol exposure: report of two cases

Received: February 26, 2010    Accepted: February 28, 2010

Azamsadat Mousavi M.D.1 Setare Akhavan M.D.2*

1- Department of Gynecology oncology, Tehran University of Medical Science.
2- Department of Obstetric and Gynecology, Kurdistan University of Medical Sciences, Besat Hospital, Sanandaj.

Background: Primary clear cell adenocarcinoma of cervix (CCAC) is usually seen in women with a history of in utero exposure to diethyl acetyl bestrol (DES). We report two cases of clear cell adenocarcinoma of cervix with no history of exposure to DES in embryonic period. (more…)

The effects of “Constraint-Induced Movement Therapy” on fine motor skills in children with hemiplegic cerebral palsy

Received: February 17, 2010    Accepted: February 20, 2010

Shahram Abootalebi M.D.1
Alireza Khoshnevisan M.D.2
Amir Hassan Kohan M.S.2*
Ebrahim Pishyareh Ph.D.3
Mehdi Rahgozar Ph.D.4

1- Department of Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences.
2- Brain And Spinal Cord Injury Repair research center (BASIR), Tehran University of Medical Sciences
3- Department of Occupational Therapy, University of Social Welfare and Rehabilitation Sciences and Institute for Cognitive Science Studies (ICSS).
4- Department of Statistics and Computer, University of Social Welfare and Rehabilitation Sciences.

Background: Constraint-Induced movement therapy (CIMT) is a promising treatment for improving upper limb function in adults after stroke and traumatic brain injury. It involves constraint of the less affected limb and intensive practice with the more affected limb. The purpose of this study on children with hemiplegic cerebral palsy (CP) was to evaluate the effects of CIMT on upper extremity and to make a comparison with conventional treatment. (more…)

Investigation of obsessive-compulsive disorder and assessment of obsessionality as a personality trait in patients with complex partial seizure

Received: January 27, 2010    Accepted: April 10, 2010

Kourosh Banihashemian M.A.*
Razieh Etesami Pour M.A.

Department of General Psychology, Jahrom Payam-e-nour University

Background: Behavioral changes in patients with epilepsy could cause comorbid psychiatric disorders such as anxiety disorders. This study is concerned with investigation of obsessive-compulsive disorders and assessment of obsessionality as a personality trait in patients with complex partial seizure. (more…)

Inhibin as a tumor marker of ovarian cancer in postmenopausal women

Received: February 22, 2010    Accepted: March 08, 2010

Mitra Modarres Gilani. M.D.
Mahshid Karimi. M.D.*

Department of Obstetrics & Gynecology, Oncology vali e asr Hospital, Tehran University of Medical Sciences.

Background: Inhibin is a dimeric glycoprotein that has a depressive effect on the anterior hypophys secretion. The level of this tumor marker is undetectable in menopause women. In patients with gynecological cancer, especially granulosa and epidermal-type (mucinous), ovarian cancers considerable increase in the serum level of inhibin has been reported. The increased level of inhibin has been reported in patients with recurrent ovarian cancer. (more…)

Plasma procalcitonin level as a predictor of treatment response in ICU patients with bacterial sepsis

Received: January 11, 2010    Accepted: March 19, 2010

Ahmad Reza Mobaien M.D.*1
Safar Shams2
(Dr. Clinical Laboratory Scientist (DCLS)

1- Department of Infectious Diseases, Zanjan University of Medical Sciences.
2- Department of Clinical Laboratory Scientist, Hamadan University of Medical Sciences.

Background: Sepsis is one of the most important causes of mortality in severely ill ICU patients. At least, a part of high mortality rate in sepsis patients is due to less specific clinical symptoms for prompt diagnosis. Recently some studies report that serum levels of procalcitonin will increase in these patients but changes of serum levels following treatments is not known. This study was designed to determin procalcitonin levels in patients with bacterial infectious disease in ICU, initially and during therapy and compare the levels during response to treatment. (more…)

Factor V leiden mutation in Behcet’s disease and the relationship with clinical manifestations

Received: January 12, 2010    Accepted: March 08, 2010

Karim Mowla M.D.1*
Mehrnoosh Zakerkish M.D.1
Alireza Samarbafzadeh Ph.D.2
Armaghan Moravej Aleali M.D.3

1- Department of Rheumatology, Golestan Hospital.
2- Department of Viroligy, School of Medicine.
3- Clinical Research Center, Golestan Hospital.

Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.

Background: Behcet’s disease (BD) is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet’s disease, and to find out it’s relationship with the clinical manifestations in Khuzestan province, Iran. (more…)

Radilogic evaluation of pedicle lumbar and spinal canal dimensions in north-west of Iran using computed tomography

Received: December 16, 2010    Accepted: February 05, 2010

Iraj Lotfinia M.D.1*
Mostafa Gavami M.D.2
Kaveh Haddadi M.D.1
Payman Vahedi M.D.1

1- Department of Neurosurgery
2- Department of Radiology

Tabriz University of Medical Sciences.

Background: Pedicular screws are currently the gold standard of internal fixation of spinal column. Pedicular screws have their own complications, however the surgeon should be aware of morphometery of pedicles, as well as the anatomy of surrounding neural structures to minimize these risks. No national study has ever examined the physical characteristics of lumbar pedicles and this study is unique for this purpose. (more…)

Assessment of PD-1 gene variation in patients with multiple sclerosis

Received: January 25, 2010    Accepted: March 13, 2010

Ashraf Ahmadi Shadmehri Msc.1
Mohammad Hosein Nicknam M.D.-PhD2
Mohammad Ali Shokrgozar PhD.3
Mehdi Mahmoudi PhD. Student.2
Shila Sarial PhD. Student.2
Azam Ahmadi Shadmehri Msc.2
Batool Moradi BS.2
Elham Farhadi Msc student.2
Ali Akbar Amirzargar PhD.2*

1- Tehran Science and Research Branch Islamic Azad University, Tehran.
2- Department of Molecular Immunology Research Center, Tehran University of Medical Sciences.
3- Pasture Institute of Iran.

Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with presumed autoimmune origin. T cells are considered to play a pivotal role in orchestrating the self-reactive immune responses in multiple sclerosis (MS). This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PD-1) gene on susceptibility to ankylosing spondylitis. This gene codes an immunoreceptor named PD-1, which has a cytoplasmic domain containing two tyrosine residues located within immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM), suggesting that PD-1 is predominantly inhibitory which responsible for the negative regulation in T cell activation and peripheral tolerance. We investigated whether PD-1 gene polymorphism is a genetic modifier for risk and progression of MS. (more…)

In-vitro anti fungal activity of Propolis alcoholic extract on Candida spp. and Aspergillus spp.

Received: February 01, 2010    Accepted: April 04, 2010

Kambiz Diba Ph.D.1*
Bita Mousavi Ph.D.2
Mohsen Mahmoudi MSPH3
Jamal Hashemi Ph.D.3

1- Department of Parasitology & Medical Mycology, School of Medicine, Uromia University of Medical Sciences.
2- Department of Parasitology & Medical Mycology, School of Medicine, Kurdistan University of Medical Sciences.
3- Department of Parasitology & Medical Mycology, School of Public Health, Tehran University of Medical Sciences.

Background: Several studies have shown that propolis has antibacterial, antifungal, antiviral and antiparasitic activity. Furthermore propolis has been described to have medicinal usages in some fungal infections like Candidiasis. Our aim is to study the inhibitory effects of alcoholic extract of propolis on Candida spp. and Aspergillus spp. (more…)

Rupture of pectoralis major muscle: review article

Received: February 22, 2010    Accepted: February 27, 2010

Mohammad Reza Guity M.D.*
Amir Reza Farhoud M.D.

Department of Orthopaedic Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences.

Background: Rupture of pectoralis major muscle is a very rare and often athletic injury. These days in our country this injury occurs more frequently. This could be due to increase in professional participation of amateur people in different types of sport, like body building and weight-lifting (especially bench-pressing) without adequate preparation, training and taking necessary precautions. In this article, we have tried to review several aspects of complex anatomy of pectoralis major muscle, epidemiology, mechanism, clinical presentations, imaging (more…)