Prevalence of hearing loss among high risk newborns hospitalized in hospitals affiliated to Tehran University of Medical Sciences

Received: August 16, 2009    Accepted: November 14, 2009

Ali Zamani M.D.1*
Alireza Karimi M.D.2
Mohsen Naseri M.D.1
Elaheh Amini M.D.3
Mohammad Milani M.D.1
Amir Arvin Sazgar M.D.2
Seyed Mousa Sadr Hosseini M.D.2
Mohammad Sadeghi Hassan Abadi M.D.2
Fatemeh Nayeri M.D.3
Firouzeh Nili M.D.3
Mamak Shariat M.D.3
Mostafa Vasigh G.P.4
Fariba Nasaj M.S.2
Fatemeh Zamani M.D.4
Narges Zamani M.D.5

1- Department of Pediatric
2- Department of ENT
3- Maternal, Fetal & Neonatal Research Center
4- General Physicians
5- Medical Students

Tehran University of Medical Sciences

Background: American pediatric Association proposes to screen all neonates with Oto-Acoustic Emission (OAE). In developing countries, because of several limitations, health policy makers recommend to screen only in high risk patients. This study is performed with the aim to screen hearing loss in 950 high risk newborns hospitalized in hospitals affiliated to Tehran University using the OAE test. (more…)

Hydrocephaly and Intraventricular hemorrhage in premature neonates    in Yazd University Hospitals

Received: October 04, 2009    Accepted: December 02, 2009

Reza Nafisi Moghaddam M.D.1
Ahmad Shajari M.D.*2
Pegah Roozbeh M.D.3

1- Department of Radiology
2- Department of Pediatrics
3- Research And Development Center

Yazd University of Medical Sciences, Yazd, Iran

Background: Cerebrovascular accidents are the most common complications in premature neonates (gestational age <37 weeks). Intraventricular hemorrhage (IVH) and hydrocephaly are the most common presentations of these accidents. Premature neonates less than 28 week age or 1000 gr have maximum risk of cerebrovascular accidents with prevalence of 30 percent. Early screening in high risk pregnancies with real-time ultrasonography can detect these lesions and affect on final prognosis. The purpose of this study is evaluation of brain ultrasonongraphic findings of 60 premature neonates born in Yazd University Hospitals, Yazd, Iran and relationship between these findings and delivery types. (more…)

A new look at an old dogma: wound complications in two methods of skin closure in uncomplicated appendicitis

Received: December 21, 2009    Accepted: February 03, 2010

Hamid Ghaderi M.D.1*
Kourosh Shamimi M.D.1
Fereydoon Moazzami M.D.1
Seyed Hasan Emami razavi M.D.1
Ali Aminian M.D.1
Seyed Mehdi Jalali M.D.1
Reza Afghani M.D.1
Morteza Noaparast M.D.1
Seyed Habibollah Dashti M.D.1
Saeed Safari M.D.1
Alireza Ahmadvand M.D.2
Seyede Adeleh MirJafari Daryasari3
Fatemeh sadat Naeemie B.S.4

1- Department of General Surgery
2- Department of Epidemiology and Biostatistics, School of Public Health
3- Medical Student
4- Researcher Assistant

Tehran University of Medical Sciences

Background: Appendicitis is more common during the second and third decade of life and appendectomy scar is important in terms of cosmetic issues. The scar is an important factor in the patient’s satisfaction. Conventional teaching has an emphasis on the closure of skin incision with “separate” sutures. The aim of this study was to reconsider this dogma. (more…)

Epidemiology of superficial and cutaneous mycosis in 5500 suspected patients in Tehran

Received: October 24, 2009    Accepted: December 02, 2009

Ayatollah Nasrollahi Omran Ph.D.1
Seyyed Jamal Hashemi Ph.D.2*
Farshad Hashemi3

1- Department of Mycology, IAU of Tonekabon Branch
2- Department of Medical Mycology, School of Public Health Research, Tehran University of Medical Sciences
3- Student of DVM, School of Veterinary Medicine, Researches and Sciences Branch, Islamic Azad University

Background: Identification of the determatophytosis species and superficial mycosis agents may be useful in directing the survey for environmental and animal sources of infection to educate the danger of acquiring infections from infected persons and other animals. Based on this background the identification of cutaneous mycosis distribution was the main purpose. (more…)

Oral candidiasis in Human Immunodeficiency Virus (HIV) infected individuals in Iran

Received: September 02, 2009    Accepted: December 16, 2009

Farzad Katiraee Ph.D.1,2*
Ali Reza Khosravi Ph.D.1
Vahid Khalaj Ph.D.3
Mahboubeh Hajiabdolbaghi M.D.4
Ali Asghar Khaksar D.V.M.2
Mehrnaz Rasoulinejad M.D.4
Mir Saeed Yekani nejad M.S.5

1- Ph.D. of Mycology, Mycology Research Center, University of Tehran
2- Department of Mycology, Pasteur Institute of Iran
3- Biotechnology Research Center, Pasteur Institute of Iran

4- IRCHA, Imam Khomeini Hospital
5- Department of Biostatistics, Institute of Public Health Research

Tehran University of Medical Sciences

Background: Oropharyngeal candidiasis is the most frequent fungal infection in HIV patients. The aims of this study were to appraise prevalence of oropharyngeal candidiasis and to determine factors associated with oropharyngeal candidiasis and oral yeast colonization among Iranian HIV patients. (more…)

A report of multiple sclerosis patients treated by CinnoVex™ in Iran

Received: October 10, 2009    Accepted: January 16, 2010

Masood Etemadifar M.D.1*
Mehrdokht Mazdeh M.D.2
Hamid Reza Torabi M.D.3
Majid Ghaffarpour M.D.4
Mojtaba Azimian M.D.4
Shiva Salami M.D.5
Sayyed Mohammad Amir Shahkarami M.D.6

1- Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Neurology, Hamedan University of Medical Sciences, Hamedan, Iran
3- Neurologist, Jam Hospital, Tehran, Iran
4- Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran
5- M.D.
6- Isfahan University of Medical Sciences, Isfahan, Iran

Background: Recent studies present a high prevalence of multiple sclerosis (MS) in Iran. Treatment with interferon is now the first choice in management of MS. CinnoVex^TM (an interferon beta 1-a) is available in Iran, with achievement of the technology of producing beta interferon. The aim of the present study is to evaluate the efficacy and safety of CinnoVex^TM in a national study named CINA study. (more…)

Number and subtypes of natural killer cells in patients with allergic rhinitis in comparison to healthy subjects

Received: December 28, 2009    Accepted: January 16, 2010

Mehrnaz Mesdaghi M.D.1*
Mohammad Vodjgani Ph.D.1
Eisa Salehi Ph.D.1
Jamshid Hadjati Ph.D.1
Abdolfattah Sarrafnejad Ph.D.2
Masoud Movahedi M.D.3
Farideh Berjisian B.S.1
Tahereh Shahrestani B.S.2

1- Department of Immunology, School of Medicine
2- Department of Immunology, School of Public Health
3- Department of Pediatrics, School of Medicine

Tehran University of Medical Sciences

Background: Allergic rhinitis is a common disorder with great morbidity. Its prevalence has increased during recent years, therefore attracting attentions to its mechanisms. Type 2 cytokines play a major role in allergies. It has been proposed that Natural killer (NK) cells may be able to produce type 2 cytokines. This study was done to evaluate NK cells number and subtypes in patients with allergic rhinitis, comparing healthy subjects. (more…)

Poly T polymorphism consideration in normal individuals and cystic fibrosis patients in Mazandaran province, Iran

Received: October 24, 2009    Accepted: January 23, 2010

Haleh Akhavan Niaki Ph.D.1*
Reza Tabaripour M.S.2
Mohammad Reza Esmaeeli Douki M.D.3
Mandana Azizi B.S.4
Javad Tavakoli Bazzaz Ph.D.5
Bagher Larijani M.D.6

1- Cellular and Molecular Biology Research Center, Babol University of Medical Sciences
2- Islamic Azad University, Science and Research Branch, Cellular and Molecular Biology Department, Tehran
3- Non-Contagious Research Center for Children, Babol University Of Medical Sciences
4- Genetic Laboratory Of Amirkola Children Hospital
5- Department of Genetic, Tehran University Of Medical Sciences
6- Endocrine Research Center, Tehran University Of Medical Sciences

Background: Cystic fibrosis is a monogenic recessive disorder founds predominantly in caucasian population causes exocrine glands function defect. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Because of heterogeneity of the mutations in CFTR gene, phenotypic symptoms in this disease are very variable. In this study we consider poly T polymorphism (T₅, T₇, T₉) in the intron 8 of CFTR gene in normal individuals and cystic fibrosis patients in mazandaran province. (more…)

The effect of long term administration of ascorbic acid on the learning and memory deficits induced by diabetes in rat

Received: January 09, 2010    Accepted: February 08, 2010

Parisa Hasanein Ph.D.1*
Siamak Shahidi Ph.D.2

1- Department of Biology, School of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran
2- Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Background: Ascorbic acid improves cognitive impairments in several experimental models. Diabetes causes learning and memory deficits. In this study we hypothesized that chronic treatment with ascorbic acid (100mg/kg, p.o) would affect on the passive avoidance learning (PAL) and memory in control and streptozocin-induced diabetic rats.

Methods: Diabetes was induced by a single i.p. injection of STZ (60mg/kg). The rats were considered diabetic if plasma glucose levels exceeded 250mg/dl on three days after STZ injection. Treatment was begun at the onset of hyperglycemia. PAL was assessed 30 days later. Retention test was done 24 h after training. At the end, animals were weighted and blood samples were drawn for plasma glucose measurement. (more…)

Applications of comparative genomic hybridization in cancer and genetic disorders: a review article

Received: January 19, 2010    Accepted: February 10, 2010

Mohammad Reza Noori-Daloii M.S., Ph.D.*
Nazanin Jalilian

Department of Medical Genetics

Tehran University of Medical Sciences, Tehran, Iran

Since the recognition of true number of human chromosomes in 1956, many techniques have been developed to detect chromosomal aberrations. A number of those, such as karyotyping and fluorescence in situ hybridization (FISH), are valuable tools in both research and diagnostics. But these techniques have defects that limit their application. One of the important limitations is resolution; resolution limitations make it impossible to detect small aberrations. The other major defect is the disability to analyze whole genome. In 1997 Solinas-Toldo introduced a new technique that could cover other techniques’ defects. (more…)