Clear cell adenocarcinoma of the cevix  without in utero diethylstilbestrol exposure: report of two cases

Received: February 26, 2010    Accepted: February 28, 2010

Azamsadat Mousavi M.D.1 Setare Akhavan M.D.2*

1- Department of Gynecology oncology, Tehran University of Medical Science.
2- Department of Obstetric and Gynecology, Kurdistan University of Medical Sciences, Besat Hospital, Sanandaj.

Background: Primary clear cell adenocarcinoma of cervix (CCAC) is usually seen in women with a history of in utero exposure to diethyl acetyl bestrol (DES). We report two cases of clear cell adenocarcinoma of cervix with no history of exposure to DES in embryonic period. (more…)

The effects of “Constraint-Induced Movement Therapy” on fine motor skills in children with hemiplegic cerebral palsy

Received: February 17, 2010    Accepted: February 20, 2010

Shahram Abootalebi M.D.1
Alireza Khoshnevisan M.D.2
Amir Hassan Kohan M.S.2*
Ebrahim Pishyareh Ph.D.3
Mehdi Rahgozar Ph.D.4

1- Department of Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences.
2- Brain And Spinal Cord Injury Repair research center (BASIR), Tehran University of Medical Sciences
3- Department of Occupational Therapy, University of Social Welfare and Rehabilitation Sciences and Institute for Cognitive Science Studies (ICSS).
4- Department of Statistics and Computer, University of Social Welfare and Rehabilitation Sciences.

Background: Constraint-Induced movement therapy (CIMT) is a promising treatment for improving upper limb function in adults after stroke and traumatic brain injury. It involves constraint of the less affected limb and intensive practice with the more affected limb. The purpose of this study on children with hemiplegic cerebral palsy (CP) was to evaluate the effects of CIMT on upper extremity and to make a comparison with conventional treatment. (more…)

Investigation of obsessive-compulsive disorder and assessment of obsessionality as a personality trait in patients with complex partial seizure

Received: January 27, 2010    Accepted: April 10, 2010

Kourosh Banihashemian M.A.*
Razieh Etesami Pour M.A.

Department of General Psychology, Jahrom Payam-e-nour University

Background: Behavioral changes in patients with epilepsy could cause comorbid psychiatric disorders such as anxiety disorders. This study is concerned with investigation of obsessive-compulsive disorders and assessment of obsessionality as a personality trait in patients with complex partial seizure. (more…)

Inhibin as a tumor marker of ovarian cancer in postmenopausal women

Received: February 22, 2010    Accepted: March 08, 2010

Mitra Modarres Gilani. M.D.
Mahshid Karimi. M.D.*

Department of Obstetrics & Gynecology, Oncology vali e asr Hospital, Tehran University of Medical Sciences.

Background: Inhibin is a dimeric glycoprotein that has a depressive effect on the anterior hypophys secretion. The level of this tumor marker is undetectable in menopause women. In patients with gynecological cancer, especially granulosa and epidermal-type (mucinous), ovarian cancers considerable increase in the serum level of inhibin has been reported. The increased level of inhibin has been reported in patients with recurrent ovarian cancer. (more…)

Plasma procalcitonin level as a predictor of treatment response in ICU patients with bacterial sepsis

Received: January 11, 2010    Accepted: March 19, 2010

Ahmad Reza Mobaien M.D.*1
Safar Shams2
(Dr. Clinical Laboratory Scientist (DCLS)

1- Department of Infectious Diseases, Zanjan University of Medical Sciences.
2- Department of Clinical Laboratory Scientist, Hamadan University of Medical Sciences.

Background: Sepsis is one of the most important causes of mortality in severely ill ICU patients. At least, a part of high mortality rate in sepsis patients is due to less specific clinical symptoms for prompt diagnosis. Recently some studies report that serum levels of procalcitonin will increase in these patients but changes of serum levels following treatments is not known. This study was designed to determin procalcitonin levels in patients with bacterial infectious disease in ICU, initially and during therapy and compare the levels during response to treatment. (more…)

Factor V leiden mutation in Behcet’s disease and the relationship with clinical manifestations

Received: January 12, 2010    Accepted: March 08, 2010

Karim Mowla M.D.1*
Mehrnoosh Zakerkish M.D.1
Alireza Samarbafzadeh Ph.D.2
Armaghan Moravej Aleali M.D.3

1- Department of Rheumatology, Golestan Hospital.
2- Department of Viroligy, School of Medicine.
3- Clinical Research Center, Golestan Hospital.

Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.

Background: Behcet’s disease (BD) is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet’s disease, and to find out it’s relationship with the clinical manifestations in Khuzestan province, Iran. (more…)

Radilogic evaluation of pedicle lumbar and spinal canal dimensions in north-west of Iran using computed tomography

Received: December 16, 2010    Accepted: February 05, 2010

Iraj Lotfinia M.D.1*
Mostafa Gavami M.D.2
Kaveh Haddadi M.D.1
Payman Vahedi M.D.1

1- Department of Neurosurgery
2- Department of Radiology

Tabriz University of Medical Sciences.

Background: Pedicular screws are currently the gold standard of internal fixation of spinal column. Pedicular screws have their own complications, however the surgeon should be aware of morphometery of pedicles, as well as the anatomy of surrounding neural structures to minimize these risks. No national study has ever examined the physical characteristics of lumbar pedicles and this study is unique for this purpose. (more…)

Assessment of PD-1 gene variation in patients with multiple sclerosis

Received: January 25, 2010    Accepted: March 13, 2010

Ashraf Ahmadi Shadmehri Msc.1
Mohammad Hosein Nicknam M.D.-PhD2
Mohammad Ali Shokrgozar PhD.3
Mehdi Mahmoudi PhD. Student.2
Shila Sarial PhD. Student.2
Azam Ahmadi Shadmehri Msc.2
Batool Moradi BS.2
Elham Farhadi Msc student.2
Ali Akbar Amirzargar PhD.2*

1- Tehran Science and Research Branch Islamic Azad University, Tehran.
2- Department of Molecular Immunology Research Center, Tehran University of Medical Sciences.
3- Pasture Institute of Iran.

Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with presumed autoimmune origin. T cells are considered to play a pivotal role in orchestrating the self-reactive immune responses in multiple sclerosis (MS). This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PD-1) gene on susceptibility to ankylosing spondylitis. This gene codes an immunoreceptor named PD-1, which has a cytoplasmic domain containing two tyrosine residues located within immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM), suggesting that PD-1 is predominantly inhibitory which responsible for the negative regulation in T cell activation and peripheral tolerance. We investigated whether PD-1 gene polymorphism is a genetic modifier for risk and progression of MS. (more…)

In-vitro anti fungal activity of Propolis alcoholic extract on Candida spp. and Aspergillus spp.

Received: February 01, 2010    Accepted: April 04, 2010

Kambiz Diba Ph.D.1*
Bita Mousavi Ph.D.2
Mohsen Mahmoudi MSPH3
Jamal Hashemi Ph.D.3

1- Department of Parasitology & Medical Mycology, School of Medicine, Uromia University of Medical Sciences.
2- Department of Parasitology & Medical Mycology, School of Medicine, Kurdistan University of Medical Sciences.
3- Department of Parasitology & Medical Mycology, School of Public Health, Tehran University of Medical Sciences.

Background: Several studies have shown that propolis has antibacterial, antifungal, antiviral and antiparasitic activity. Furthermore propolis has been described to have medicinal usages in some fungal infections like Candidiasis. Our aim is to study the inhibitory effects of alcoholic extract of propolis on Candida spp. and Aspergillus spp. (more…)

Rupture of pectoralis major muscle: review article

Received: February 22, 2010    Accepted: February 27, 2010

Mohammad Reza Guity M.D.*
Amir Reza Farhoud M.D.

Department of Orthopaedic Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences.

Background: Rupture of pectoralis major muscle is a very rare and often athletic injury. These days in our country this injury occurs more frequently. This could be due to increase in professional participation of amateur people in different types of sport, like body building and weight-lifting (especially bench-pressing) without adequate preparation, training and taking necessary precautions. In this article, we have tried to review several aspects of complex anatomy of pectoralis major muscle, epidemiology, mechanism, clinical presentations, imaging (more…)