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Table of Contents >> Tehran University Medical Journal (TUMJ), Volume 72, Number 6, September 2014

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Mesenchymal stem cells and their application in autoimmune disease treatment: review article
Tayebi Kamardi M, Pourgholaminejad A, Baghban Eslaminejad M.R, Sotoodehnejadnematalahi F.

Production of extracellular matrix powder for tissue engineering
Sadighi S, Tavaccoli A.H, Dadash poor N, Hosieny K.

Association between G-2548A leptin gene polymorphism and breast cancer risk
Rostami S, Kohan L, Mohammadian Panah M, Fereiduni F.

Amniotic membrane seeded with mesenchymal adipose-derived stem cell for coverage of wound in third degree burn: An experimental study
Fatemi M.J, Khajerahimi A.A, Nikoumaram B, Sakhaei M, Mostafavi Sh, Atashi A, Pedram M.S, Aghayan S.H.R, Araghi Sh, Soltani M, Mossahebi Mohammadi M.

Histological and biochemical characteristics of arteries and veins in patients candidate for coronary bypass surgery
Dana N, Safavi Sh, Nili N, Seyed Tabatabaei B.E, Haghjooy Javanmard Sh.

Endometrial morphology following repeated ovarian stimulation in mouse
Alizadeh Z, Kheradmand Z, Bahmanzadeh M, Sohrabi M, Esna Ashari F, Dehghan A.

Sensitivity and specificity of endoscopy in diagnosis for Barrett’s esophagus
Sharifi A, Dolatshahi Sh, Rezaeifar A, Ramim T.

Correlation between retinopathy of prematurity and clinical risk index for babies score
Ahmadpour-kacho M, Zahed Pasha Y, Rasoulinejad S.A, Hajiahmadi M, Pourdad P.

Comparison of androgenic alopecia distribution among type 2 diabetes and healthy women in Isfahan city: a brief report
Jafari F, Nilforooshzade M.A, Porajam S, Heidari-Beni M.

Assessment of Tuberculosis distribution by geographical information system in Khuzestan province: a brief report
Beiranvand R, Delpisheh A, Sayehmiri K, Weysi K, Ghalavandi Sh.


Assessment of Tuberculosis distribution by geographical information system in Khuzestan province: a brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 September;72(6):417-22

Author Affiliations:
Reza Beiranvand M.Sc.1,2
Ali Delpisheh Ph.D., PostDoc1*
Samira Solymani M.Sc.3
Kourosh Sayehmiri Ph.D.4
Keywan Weysi M.Sc.5
Shahnaz Ghalavandi B.Sc.6

1- Department of Epidemiology, Favulty of Health, Ilam University of Medical Sciences, Ilam, Iran.
2- Student’s Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
3- Environmental Engineering, Favulty of Health, Ilam University of Medical Sciences, Ilam, Iran.
4- Prevention of Psychosocial Injuries, Research Center, Ilam, Iran.
5- Department of Environmental Health Engineering, Ilam University of Medical Sciences, Ilam, Iran.
6- Jundishapur University of Medical Sciences, Ahvaz, Iran.

*Corresponding author: Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
Mailbox: 69315-138
Tel: +98- 841- 2227103
E-mail: alidelpisheh@yahoo.com

Received: 31 May. 2014    Accepted: 11 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Distribution of Tuberculosis (TB) has a special template affected by geographic and social factors. Nowadays Geographical Information System (GIS) software is one of the most important and useful epidemiologic devise for identifying geographic areas and high risk population for infection by TB. Aim of this study was assessment of Tuberculosis distribution by GIS in Khuzestan province, Iran. (more…)


Comparison of androgenic alopecia distribution among type 2 diabetes and healthy women in Isfahan city: a brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 September;72(6):412-16

Author Affiliations:
Fariba Jafari M.D.1*
Mohammad-Ali Nilforooshzade M.D.1,2
Samane Porajam M.D.3
Motahar Heidari-Beni Ph.D. Student4

1- Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Isfahan University of Medical Sciences, Isfahan, Iran.
4- Food Security Research Center, Department of Community nutrition, School of Nutrition & Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

*Corresponding author: Isfahan, Jomhori Square, Sedighe Tahere Research Center. Skin and Leishmania Research Center, Isfahan, Iran.
Tel: +98- 311- 3377766
E-mail: Jaffary@pharm.mui.ac.ir

Received: 11 Feb. 2014    Accepted: 29 Jun. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Insulin resistant is important risk factors of diabetes and leads to development of chronic diseases such as diabetes and cardiovascular disease. Recent studies showed association between androgenic alopecia and insulin resistant. However, findings are controversial. Alopecia in women is a common heritable hair loss in central part of head. Aim of this study was investigation of androgenic alopecia distribution in type II diabetes and healthy women and hypothesis testing of relationship between diabetes and androgenic alopecia. (more…)


Correlation between retinopathy of prematurity and clinical risk index for babies score

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):404-11

Author Affiliations:
Mousa Ahmadpour-kacho M.D.1*
Yadollah Zahed Pasha M.D.1
Seyed Ahmad Rasoulinejad M.D.2
Mahmoud Hajiahmadi Ph.D.3
Parisa Pourdad M.Sc.4

1- Non-Communicable Pediatric Disease Research Center, Department of Pediatrics, Amirkola Children’s Hospital, Babol University of Medical Sciences, Babol, Iran.
2- Retinologist, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
3- Department of Biostatistics, Non-Communicable Pediatric Disease Research Center, Babol University of Medical Sciences, Babol, Iran
4- Student of Neonatal Intensive Care Nursing , Amirkola Children’s Hospital, Babol University of Medical Sciences, Babol, Iran.

*Corresponding author: Non-Communicable Pediatric Diseases Research Center, No 19, Amirkola Children’s Hospital, Amirkola, Babol, Mazandaran Province, 47317-41151, Iran.
Tel: +98- 11- 32342007
E-mail: mousa_ahmadpour@hotmail.com

Received: 03 May. 2014    Accepted: 16 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Several risk factors like prematurity, hyperoxia, hyperglycemia, duration of mechanical ventilation and supplemental oxygen use have been attributed to the occurrence of retinopathy of prematurity (ROP) in low birth weight infants. Clinical Risk Index for Babies (CRIB) score have been used to assess the severity of the newborn’s disease and neonatal mortality. The relation between the CRIB score and the incidence of retinopathy of prematurity is less assessed. This study was carried out to determine the relation between the CRIB score and retinopathy of prematurity in preterm infants. (more…)


Sensitivity and specificity of endoscopy in diagnosis for Barrett’s esophagus

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):396-403

Author Affiliations:
Alireza Sharifi M.D.1
Shahab Dolatshahi M.D.1
Atefeh Rezaeifar M.D.1
Tayeb Ramim M.D.2*

1- Department of Gastroenterology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

*Corresponding author: Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave., Tehran, Iran.
Tel: +98- 21- 66757001
E-mail: tayebramim@yahoo.com

Received: 30 Jun. 2014    Accepted: 11 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Lack of precise diagnostic criteria and sufficient findings in support of biopsy sampling during upper gastrointestinal endoscopy is one of the special challenge in endoscopy assessment in Barrett’s esophagus. The aim of this study was to evaluate the mucosa in the distal esophagus tissues through a biopsy during upper gastrointestinal endoscopy in gastroesophogeal reflux disease patients whose symptoms don’t improve or only partially resolve with treatment. (more…)


Endometrial morphology following repeated ovarian stimulation in mouse

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):389-95

Author Affiliations:
Zohreh Alizadeh Ph.D.1*
Zohreh Kheradmand M.D.2
Maryam Bahmanzadeh Ph.D.3
Maryam Sohrabi Ph.D.3
Farzaneh Esna Ashari Ph.D.4
Arash Dehghan M.D.5

1- Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
4- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
5- Department of Pathology, School of Medicine Hamadan University of Medical Sciences, Hamadan, Iran.

*Corresponding author: Department of Anatomcal Sciences, School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh St., P.O.Box. 65178-518, Hamadan. Iran.
Tel: +98- 81- 38380583
E-mail: alizadeh@umsha.ac.ir

Received: 02 Jun. 2014    Accepted: 30 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Gonadotropins are commonly used for superovulation in human and animals to retrieve more oocyte and increase chance of pregnancy. Ovarian stimulation in assisted reproduction technology produces lower implantation rates per embryo transferred than natural and ovum donation cycles, suggesting suboptimal endometrial development due to the hormones used to recruit more oocytes. Due to the frequent use of gonadotropins in the treatment of infertility in successive periods, the aim of this study was to determine the endometrial changes in response to repeated ovarian stimulation. (more…)


Histological and biochemical characteristics of arteries and veins in patients candidate for coronary bypass surgery

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):379-88

Author Affiliations:
Nasim Dana Ph.D.1
Shiva Safavi M.Sc.2
Nafiseh Nili Ph.D.1,2
Badrodin Ebrahim Seyed Tabatabaei Ph.D.2
Shaghayegh Haghjooy Javanmard M.D., Ph.D.1*

1- Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Agricultural Biotechnology, College of Agriculture, Isfahan University of
Technology, Isfahan, Iran.

*Corresponding author: Applied Physiology Research Center, Isfahan University of Medical Sciences, Hezar jarib Avenue, Isfahan, Iran.
Tel: +98- 31- 37922295
E-mail: sh_haghjoo@med.mui.ac.ir

Received: 10 Jun. 2014    Accepted: 30 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: The occlusion of the artery and vein grafts are currently a major problem in coronary bypass surgery. Degradation of collagen and elastin, the most abundant extracellular matrix proteins in the vessel wall by matrix metalloproteinase (MMPs), leads to a rearrangement of the extracellular matrix and vascular wall structure. The present study aimed to compare the histological and biochemical characteristics of arteries and veins which could have a role in the failure of the graft. (more…)


Amniotic membrane seeded with mesenchymal adipose-derived stem cell for coverage of wound in third degree burn: An experimental study

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):367-78

Author Affiliations:
Mohammad Javad Fatemi M.D.1
Amir Asadollah Khajerahimi M.D.2
Babak Nikoumaram M.D.2
Maryam Sakhaei M.D.3
Shabnam Mostafavi M.D.3
Amir Atashi Ph.D.4*
Mir sepehr Pedram DVM-DVSc.5
Seyed Hamid Reza Aghayan M.D.,Ph.D.6
Shirin Araghi B.Sc.7
Majid Soltani M.D.3
Majid Mossahebi Mohammadi M.Sc.8

1- Department of Plastic & Reconstructive Surgery, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Plastic & Reconstructive Surgery, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
3- General Practitioner, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
5- Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
6- Chronic Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences & SinaCell knowledge Based company, Tehran, Iran.
7- Department of Nursing, Hazrat Fatima Hospital, Burn Research Center, Tehran, Iran.
8- Department of Stem cell Biology, Stem cell Technology Research center, Tehran, Iran.

*Corresponding author: Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Jalale Ale Ahmad Highway, Tehran, Iran.
Tel: +98- 21- 82883579
E-mail: atashia@modares.ac.ir

Received: 26 Apr. 2014    Accepted: 16 Aug. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Stem cells are applied in the treatment of wide range of diseases and can be separated from different tissues of the body. These cells can treat diseases by cytokine and growth factor secretion and also cell differentiation. Burn wound is a challenging problem of reconstructive surgery and stem cells may help wound healing process. We designed this study to evaluate the beneficial effect of fat derived stem cells for coverage of 3rd degree burn wound. (more…)


Association between G-2548A leptin gene polymorphism and breast cancer risk

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):360-6

Author Affiliations:
Sara Rostami M.Sc.1,3
Leila Kohan Ph.D.1,3*
Mohammad Mohammadian Panah M.D.2
Fereshteh Fereiduni B.Sc.1

1- Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.
2- Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Yong Researchers and Elite Club, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.

*Corresponding author: Department of Biology, Islamic Azad University, Arsanjan Branch, University Blvd., Arsanjan
Tel: +98- 729- 7623909
E-mail: kohan@iaua.ac.ir

Received: 11 Jun. 2014    Accepted: 07 Jul. 2014    Available online: 11 Sep. 2014

Abstract:
Background: Leptin is an adipokine made by fat cells and plays a key role in proliferation, cell survival, migration and immune response. Several studies have suggested that individuals with high serum leptin concentrations would increase the risk of breast cancer. G -2548A polymorphism in the leptin gene is located in the promoter region and is associated with the change of leptin serum level. In this study, the association between G -2548A polymorphism in leptin gene and breast cancer susceptibility was investigated. (more…)


Production of extracellular matrix powder for tissue engineering

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Original Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):352-9

Author Affiliations:
Sanambar Sadighi M.D.1*
Amir Hosien Tavaccoli M.D.2
Nayer Dadash poor M.A.3
Kazem Hosieny M.Sc.4

1- Department of Internal Medicine, Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Psychiatric, Tissue Bank And Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Molecular Biology, Tehran Azad University of Research and Sciences, Tehran, Iran.
4- Researcher of Tissue Bank Research Center, Tehran, Iran.

*Corresponding author: Medical Oncol-ogy Ward-Cancer Institute-Imam Kho-meini Complex-Gharib Ave-Keshavarz Blvd., Tehran, Iran.
Tel: +98- 21-61192763
E-mail: ssadighi@tums.ac.ir

Received: 10 Feb. 2014    Accepted: 13 Jul. 2014    Available online: 11 Sep. 2014

Abstract:
Background: With the aim of regenerating healthy tissues, different tissue engineering strategies pointed to extracellular matrix (ECM)-based scaffolds in tissue engineering and regenerative medicine and wound healing. It is a multidisciplinary science works to create biocompatible scaffolds with perfect physical parameters, mechanical integrity and high porosity to promote cell growth, migration and angiogenesis. With the increased incidence of obesity, subcutaneous adipose tissue is abundant and readily accessible. Liposuction surgeries yield from 100 mL to 3 L of lipoaspirate tissue. We present our prepared acellular ECM powders derived from human adipose tissue obtained from lipoaspirate, which contains large amounts of collagen suitable for induction of adipogenesis. (more…)


Mesenchymal stem cells and their application in autoimmune disease treatment: review article

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Review Article

Tehran Univ Med J (TUMJ) 2014 September;72(6):341-51

Author Affiliations:
Mehrnaz Tayebi Kamardi M.Sc.  Student1
Arash Pourgholaminejad Ph.D. Student1,2
Mohammadreza Baghban Eslaminejad Ph.D.1
Fattah Sotoodehnejadnematalahi Ph.D.1*

1- Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
2- Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

*Corresponding author: Department of Stem Cells and Developmental Biology, Royan Institute, Banihashem Sq., Banihashem St., Resalat highway, P.O. Box: 19395-4644, Tehran, Iran.
Tel: +98- 21- 22306685
E-mail: fattah212@gmail.com

Received: 11 Feb. 2014    Accepted: 14 Jun. 2014    Available online: 11 Sep. 2014

Abstract:
Mesenchymal Stem Cells (MSCs) are well known as the regulator of the immune system. These multipotent non-hematopoietic progenitor cells have been originally isolated from bone marrow, and later on found in several other tissues, such as skeletal muscle, umbilical cord blood, adipose and fetal liver tissues. Immunomodulatory effects of MSCs on a variety of immune cells such as T and B lymphocytes, Natural Killer cells (NK), neutrophils, macrophages and dendritic cells, has made a good candidate of them for the treatment of inflammatory disorders, particularly autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In addition, several studies have indicated mechanisms by which MSCs could reduce immune cell proliferation and activation leading to immune tolerance induction. Since T lymphocytes are considered as the most important immune cells, effect of MSCs on the activity of these cells has a very special significance to direct immune response. (more…)