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Table of Contents >> Tehran University Medical Journal (TUMJ), Volume 72, Number 8, November 2014

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Induced pluripotent stem cells, from generation to application: review article
Moradi Sh, Baharvand H.

Association of Glutathione S-transferase P1 gene polymorphism (Ile105Val) with uterine leiomyoma in Iranian population
Mostafavi Dehraisi S, Sadat S.M, Davari Tanha F, Aghasadeghi M.R, Safarpour M, Abbasi Ranjbar P, Ebrahimi A.

Relation of red blood cell’s folate and methylenetetrahedrofolate reductase C677T polymorphism to colorectal adenoma
Mazloom Z, Tabei S.M.B, Bahmanpour S, Tabatabaee H.R, Alizadeh Naeni M.

The frequency of G691S/S904S Haplotype of RET proto-oncogene in medullary thyroid carcinoma patients in Iranian population
Sheikholeslami S, Zarif Yeganeh M, Hoghooghi Rad L, Daneshpour M.S, Hedayati M.

Cytokinesis blocked micronucleus assay for evaluation of chromosomal breaks in esophageal cancer
Emamgholizadeh Minaei S, Mozdarani H, Aghamiri S.M.R, Motazakker M, Mansouri M.

Serum lead levels of cord blood in newborn immediately after birth
Khosravi N, Khalesi N, Noorbakhsh S, Tabatabaei A, Ahmadi B, Asgarian R, Javadi-nia Sh.

The frequency of clinical and laboratory findings of hypernatremia and factors affecting its severity in term newborns
Borna H, Rafati Sh, Haj Ebrahim Tehrani F.

Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers
Meralizadeh S, Mirmohammadkhani M, Naderi Eram M, Noripour Sh.

Nail Involvement in mycosis fungoides: brief report
Ehsani A.H, Gholamali F, Hosseini M.S, Nouri M, Noormohammadpour P.

Prevalence of cardiovascular risk factors in patients undergoing CABG: brief report
Yaribeygi H, Taghipour H, Taghipour H.R.


Prevalence of cardiovascular risk factors in patients undergoing CABG: brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 November;72(8):570-4

Author Affiliations:
Habib Yaribeygi Ph.D.1
Hojjat Taghipour M.Sc.2
Hamidreza Taghipour M.D.3*

1- Neuroscience Research Center, Baqiyatallah University of Medical Science, Tehran, Iran.
2- Faculty of Medicine, Baqiyatallah University of Medical Science, Tehran, Iran.
3- Cardiovascular Surgeon, Faculty of Medicine, Baqiyatallah University of Medical Science, Tehran, Iran.

*Corresponding author: Baqiyatallah Hospital, Mollasadra St., Vanak Sq., Tehran, Iran.
Tel: +98- 21- 81263491
E-mail: h_taghipour@yahoo.com

Received: 28 Jan. 2014    Accepted: 25 Jun. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Cardiovascular complications have very high incidence and are the main cause of mortality in human. Although the cardiovascular risk factors among apparently healthy subjects have been studied, these factors among patients who have undergone coronary artery bypass graft surgery have not evaluated clearly. (more…)


Nail involvement in mycosis fungoides: brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 November;72(8):564-9

Author Affiliations:
Amir Houshang Ehsani M.D.1
Fatemeh Gholamali M.D.1
Mahboubeh Sadat Hosseini M.D.2
Mojgan Nouri M.D.3
Pedram Noormohammadpour M.D.1*

1- Department of Dermatology and Immunobullous Research Center, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran.
2- Department of Endocrinology, Baqiyatallah Hospital, Tehran, Iran.
3- General Practitioner, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran.

*Corresponding author: Hafiz Ave., Vahdat-e-Eslami St., Vahdat-e-Eslami Sq., Razi Hospital, Tehran, Iran.
Tel: +98- 21- 5561898
E-mail: normohamad@razi.tums.ac.ir

Received: 06 Jun. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Mycosis fungoides (MF) is the commonest T-Cell lymphoma (CTCL) involving skin and its appendages to variable degrees. Nail involvement is one of multiple dermatologic manifestation of this disorder and could have negative impact on psychological status of patients and producing therapeutic challenge to physician. We aimed to evaluate prevalence and subtypes of nail involvement in MF patients attending dermatology clinic, Razi Hospital in Tehran, Iran. (more…)


Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):555-63

Author Affiliations:
Semira Mehralizadeh M.D.1
Majid Mirmohammadkhani M.D., Ph.D.2
Maryam Naderi Eram M.D.3*
Shamsollah Noripour M.D.4

1- Department of Cardiology, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran.
2- Research Center of Social Determinants of Health, Epidemiologist, Medical School, Semnan University of Medical Sciences, Semnan, Iran.
3- Department of Pediatrics, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran.
4- Department of Neonatology, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran.

*Corresponding author: No.3, Darban 1 alley, Feiz Garden, Semnan, Iran. Postal code: 3513663344
Tel: +98- 23- 33338952
E-mail: ma_na_er79@yahoo.com

Received: 03 Feb. 2014    Accepted: 25 Jun. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Gestational diabetes is associated with increased risk of congenital heart disease in neonates. The study was performed to evaluate the cardiac parameters in neonates of mothers with abnormal glucose tolerance test (GTT) and compare them with data of normal newborn. (more…)


The frequency of clinical and laboratory findings of hypernatremia and factors affecting its severity in term newborns

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):546-54

Author Affiliations:
Hajieh Borna M.D.*
Shiva Rafati M.D.
Fathemeh Haj Ebrahim Tehrani M.D.

Department Pediatric, Shahed University, Mostafa Khomeini Hospital, Tehran, Iran.

*Corresponding author: Mostafa Khomeini Hospital, Italia Ave., Tehran, Iran.
Tel: +98- 21- 88966130-9
E-mail: hbborna@yahoo.com

Received: 21 Jul. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Hypernatremic dehydration in neonate is a serious potentially life treating can damage the central nervous system. The aim of this study was to determine the clinical and laboratory signs of hypernatremic dehydration in term infant.

Methods: A cross sectional study was performed from April 2010 to March 2012 in 111 neonates with sodium>145 mmol/l who were admitted at the Mostafa Khomeini and Hazrat Zainab Hospitals in Tehran. The incidence of clinical and laboratory findings and relationship between some risk factors influencing the severity of hypernatremia were reviewed. The patients were subdivided in two groups: Na<150 mmol/l (group 1) and Na≥150 mmol/l (group 2). Premature infants less than 37 weeks, congenital malformations, formula fed, sepsis and organic disease were excluded. The Student’s t-test, Mann-Whitney U test and Chi-square test were used for statistical data analysis. P<0.05 were considered significant. (more…)


Serum lead levels of cord blood in newborn immediately after birth

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):540-5

Author Affiliations:
Nastaran Khosravi M.D.1
Nasrin Khalesi M.D.2
Samileh Noorbakhsh M.D.1
Azardokht Tabatabaei M.Sc. 1
Bahman Ahmadi M.D.1
Ramin Asgarian M.D.1
Shima Javadi-nia M.D.1*

1- Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Neonatal Dis-eases, Ali-Asghar Hospital, Iran University of Medical Sciences, Te-hran, Iran.

*Corresponding author: Hazrat-e-Rasool Akram Hospital, Niayesh St., Sattarkhan Ave., Iran University of Medical Sciences and Health Services, Tehran, Iran.
Tel: +98- 21- 66516049
E-mail: cpidir@gmail.com

Received: 07 Jul. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Assessment of the serum lead’s concentration in the newborn immediately after birth can be effective for the detection of lead poisoning in the early stages and prevent of developmental disorders and neuropsychiatric behaviors. This study aimed to assess the serum lead levels of cord blood in some of the hospitalized newborns. (more…)


Cytokinesis blocked micronucleus assay for evaluation of chromosomal breaks in esophageal cancer

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):533-39

Author Affiliations:
Soraya Emamgholizadeh Minaei M.Sc.1
Hossein Mozdarani Ph.D.2*
Seyed Mahmoud Reza Aghamiri Ph.D.3
Morteza Motazakker Ph.D.4
Mohsen Mansouri M.D.5

1- Department of Radiobiology and Radiation Protection, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
3- Department of Nuclear Physics, Faculty of Nuclear Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Clinical Virology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
5- Department of Oncology and Radiotherapy, Omid Center, Urmia, Iran.

*Corresponding author: Faculty of Medical Sciences, Tarbiat Modares University, Jalal-e-Ale Ahmad Highway, Tehran, Iran.
Tel: +98- 21- 82883830
E-mail: mozdarah@modares.ac.ir

Received: 09 Apr. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Radiotherapy can cause DNA damage in normal cells, misrepaired or unrepaired double strand breaks in DNA lead to chromosomal breaks. As a result patient experience early and late effects in normal tissue during and after radiotherapy. Cytogenetic techniques can be used as a cancer predictive assay because there is an association between chromosome abnormalities and the risk of developing cancer. Also it can assess patient’s complications during the therapy. The aim of the present study was evaluation of the cytogenetic alteration in peripheral blood lymphocytes of esophageal cancer patients treated with radiotherapy. (more…)


The frequency of G691S/S904S Haplotype of RET proto-oncogene in medullary thyroid carcinoma patients in Iranian population

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):526-32

Author Affiliations:
Sara Sheikholeslami M.Sc.
Marjan Zarif Yeganeh M.Sc.
Laleh Hoghooghi Rad M.Sc.
Maryam Sadat Daneshpour Ph.D.
Mehdi Hedayati Ph.D.*

Cellular and Molecular Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

*Corresponding author: Cellular and Molecular Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Parvaneh street, Yaman St., Velenjak, Chamran highway, Tehran, Iran.
Postal code: 1985717413.
Tel: +98- 21- 2243500
E-mail: hedayati@endocrine.ac.ir

Received: 06 Jun. 2014    Accepted: 19 Oct. 2014    Available online: 11 Nov. 2014

Abstract:
Background: Medullary thyroid carcinoma (MTC) occurs in both sporadic (75%) and hereditary (25%) forms. The missense mutations of the rearranged during transfection (RET) proto-oncogene in MTC development have been well demonstrated. Several studies have been published that indicate the molecular analysis of RET gene may offer early identification of those patients at high risk to develop MTC and may provide the opportunity for early intervention. The aim of this study was to investigate frequency of G691S/S904S haplotype in MTC patients and their relatives. (more…)


Relation of red blood cell’s folate and methylenetetrahedrofolate reductase C677T polymorphism to colorectal adenoma

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):515-25

Author Affiliations:
Zohreh Mazloom Ph.D.1*
Seyed Mohammad Bagher Tabei Ph.D.2
Salmeh Bahmanpour Ph.D. Candidate1
Hamid Reza Tabatabaee M.Sc.3
Mahvash Alizadeh Naeni M.D.4

1- Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Gastroenterology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

*Corresponding author: Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences, Razi Blvd., Shiraz, Iran.
Tel: +98- 71-36314923
E-mail: zmazloom@susms.ac.ir

Received: 30 May. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background
: Red Blood Cell’s (RBC)’s folate may be related to decreased risk of colorectal adenoma. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. The MTHFR C677T polymorphism is located in the Exon 4 region and is associated with the change of folate level. This study evaluated the associations between RBC’s Folate levels and colorectal adenoma risk, taking into account whether this associations is modified by MTHFR Polymorphism. (more…)


Association of Glutathione S-transferase P1 gene polymorphism (Ile105Val) with uterine leiomyoma in Iranian population

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Original Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):508-14

Author Affiliations:
Salva Sadat Mostafavi Dehraisi M.Sc.1
Seyed Mehdi Sadat Ph.D.2
Fatemeh Davari Tanha M.D.3
Mohammad Reza Aghasadeghi Ph.D.2
Mahdi Safarpour M.Sc.4
Parinaz Abbasi Ranjbar M.Sc.5
Ahmad Ebrahimi Ph.D.4*

1- Department of Genetic, Islamic Azad University, Ahar Branch, Ahar, Iran.
2- Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
3- Department of Obstetrics, Gynecologist, and Reproductive Endocrinology, Valiasr Reproductive Health Center, Tehran, University of Medical Science, Tehran, Iran.
4- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of Cellular and Molecular Biology, University of Guilan, Rasht, Iran.

*Corresponding author: Cellular and Molecular Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tel: +98- 21- 22432500
E-mail: ae35m@yahoo.com

Received: 10 Apr. 2014    Accepted: 21 Sep. 2014    Available online: 11 Nov. 2014

Abstract:
Background
: Uterine leiomyoma is one of the most common benign smooth muscle tumors occurring in 20-40% of women worldwide in their reproductive years. Recent studies revealed that estrogen plays an important role in the pathogenesis of this disease. Since glutathione S-transferase (GST) gene family are involved in the biosynthesis of estrogen, the prior probability that variants at this locus are associated with uterine leiomyoma is likely to be above the null. Therefore, this study was carried out to examine whether GSTP1 polymorphism (Ile105Val) is associated with increased risk of uterine leiomyoma in Iranian population. (more…)


Induced pluripotent stem cells, from generation to application: review article

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Review Article

Tehran Univ Med J (TUMJ) 2014 November;72(8):497-507

Author Affiliations:
Sharif Moradi M.Sc.
Hossein Baharvand Ph.D.*

Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran.

*Corresponding author: Royan Institute, Banihashem Sq., Banihashem St., Ressa-lat high-way, Tehran, Iran.
Tel: +98- 21- 22306485
E-mail: baharvand@royaninstitute.org

Received: 08 Mar. 2014    Accepted: 25 Jun. 2014    Available online: 11 Nov. 2014

Abstract:
Embryonic stem cells are pluripotent stem cells which have the ability to indefinitely self-renew and differentiate into all differentiated cells of the body. Regarding their two main properties (unlimited self-renewal and multi-lineage differentiation), these cells have various biomedical applications in basic research and cell based therapy. Because the transplantation of differentiated cells that are derived from embryonic stem cells is allogenic, they face the problem of immune rejection following the transplantation of embryonic stem cell-derived cells into patients. In 2006, researchers from Japan reported the derivation of a new type of pluripotent stem cells which could overcome the problem of immune rejection that is associated with the application of embryonic stem cells. (more…)