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Table of Contents >> Tehran University Medical Journal (TUMJ), Volume 72, Number 5, August 2014

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Role of the immune cells, mediators and cytokines in pathogenesis of asthma:  a review article
Bahrami Mahne S, Mahdaviani S.A, Rezaei N.

The effects of lactobacillus suppositories in the recovery and recurrence of bacterial vaginosis: a double-blind randomized clinical trial
Roozafzay S, Hekmat Kh, Shojaei K, Afshari P, Bahadoram M.

Design, construction and expression of recombinant vector containing the rabies virus nucleoprotein gene
Fanayi Kh, Ajorloo M, Mozhgani S.H.R, Irani Sh, Gholami A.

miRNA-21 expression analysis in 35 colorectal cancer
Samadaian N, Modaresi M.H, Mobasheri M, Ebrahim Zadeh Vesal R, Akrami S.M.

Pulmonary regurgitation after balloon valvuloplasty in children with pulmonary stenosis
Ghaderian M, Meraji M, Arabi Moghadam M.Y, Keikha M.

Preventive effects of tomato pulp on oral pre-neoplastic changes induced by 4-Nitroquinoline-1-oxid  in the rat
Mashayekhi M, Mohajeri D, Valilu M.R.

Fetal gender screening based on placental location by 2-dimentional ultrasonography
Mohammad Jafari R, Barati M, Bagheri S, Shajirat Z.

Medical malpractice frequency in the psychiatric field, in Medical Council of Iran, from 2001 to 2010:  a brief report
Sadr S.Sh, Ghadyani M.H, Avish Sh, Ramim T.

Metastatic choriocarcinoma in the small bowel:  a case report
Yousefi Z, Ghasemian Mehrdizaj S, Bidar Frimany M, Rashidi Fakari F.


Metastatic choriocarcinoma in the small bowel: a case report

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Case Report

Tehran Univ Med J (TUMJ) 2014 August;72(5):335-9

Author Affiliations:
Zohreh Yousefi M.D.1
Sedighe Ghasemian Mehrdizaj M.D.2*
Mohamad Bidar Frimany M.D.3
Farzaneh Rashidi Fakari M.Sc.4

1- Department of Gynecology Oncology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Department of Clinical Pathology, Mashhad, Iran.
4- Department of Midwifery, Mashhad Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Student Research Committee, Mashhad, Iran.

* Corresponding author: Department of Obstetrics and Gynecology, Ghaem Hospital, Ahmad Abad St., Mashhad, Iran.
Tel: +98-21-511-8430569
E-mail: ghasemians901@mums.ac.ir

Received: 28 Oct. 2013    Accepted: 08 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Choriocarcinoma is a highly malignant form of gestational trophoblastic disease. It is characterized by metastatic potential, rapid growth and deeply invasion into blood vessel and then widespread dissemination metastasis. However, the most common sites of metastatic choriocarcinoma are lung, vagina, liver, and brain. But, metastatic choriocarcinomas rarely is extended to gastrointestinal system. It is important to keep in mind that despite extensive metastasis, choriocarcinoma is very curable disease. Due to high responsibility of this disease, early diagnosis of choriocarcinoma and treatment with chemotherapy can prevent mortality and morbidity of these patients. In this case report, we present a rare case of metastatic choriocarcinoma in the small bowel after normal term pregnancy. (more…)


Medical malpractice frequency in the psychiatric field, in Medical Council of Iran, from 2001 to 2010: a brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 August;72(5):329-34

Author Affiliations:
Seyed Shahabedin Sadr M.D., Ph.D.1
Mohammad Hassan Ghadyani M.D.2
Shokroallah Avish M.D.3
Tayeb Ramim M.D.4*

1- Department of Physiology, Tehran University of Medical Sciences, Medical Council of Islamic Republic of Iran, Tehran, Iran.
2- Department of Internal Medicine, Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran.
3- Department of Emergency Medicine, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.
4- Researcher, Sina Trauma and Surgery Researches Center, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave., Tehran, Iran.
Tel: +98-21-66757001-3
E-mail:dr.tayebramim@gmail.com

Received: 05 Mar. 2014    Accepted: 16 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Identify the causes of complaints and contributing factors may reduce medical litigation. The aim of this study was to assess the cases of complaints in the field of psychiatric. (more…)


Fetal gender screening based on placental location by 2-dimentional ul-trasonography

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):323-8

Author Affiliations:
Razieh Mohammad Jafari M.D.
Mojgan Barati M.D.
Saeed Bagheri M.D.
Zeinab Shajirat M.Sc.*

Department of Obstetrics & Gynecology, Fertility Infertility and Perinatology Research Center, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

* Corresponding author: Department of Obstetrics & Gyenecology, Fertility In-fertility and Perinatology Research Center, Imam Khomeini Hospital, Azadegan Blvd., Ahvaz, Iran.
Tel: +98-611-2216504
E-mail: zeinab.shajirat@gmail.com

Received: 18 May. 2014    Accepted: 16 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Early detection of fetal gender can provide an alarm for parents who complicated by genetic disorders. Moreover, the invasive tests are used for detecting any sex-specific genetic syndromes before 12 weeks of gestation. This study was designed to discover any association between placental location and fetal gender between 11 to 13+6 weeks of gestation. (more…)


Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):314-22

Author Affiliations:
Mohammad Mashayekhi Ph.D.1*
Daryoush Mohajeri Ph.D.2
MohammadReza Valilu Ph.D.2

1- Department of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
2- Department of Pathobiology, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

* Corresponding author: Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran, P.O. Box: 5157944533
Tel: +98-411-6373339
E-mail: mashayekhi@iaut.ac.ir

Abstract:
Background: Squamous cell carcinoma (SCC) is the most frequent oral cancer. Protective effects of the consumption of vegetables and fruits on various forms of cancer including oral cancer have been determined. Tomato (Solanum lycopersicum L.) because of its lycopene and bioflavonoids contents possesses anti-carcinogenic properties. The aim of this study was to evaluate the preventive effects of tomato pulp on pre-neoplastic changes induced by 4-Nitroquinoline-1-oxid (4-NQO) in epithelial cells of lingual mucosa in the rats. (more…)


Pulmonary regurgitation after balloon valvuloplasty in children with pul-monary stenosis

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):307-13

Author Affiliations:
Mehdi Ghaderian M.D.1*
Mahmood Meraji M.D.1
Mohammad-Yoosef Arabi Moghadam M.D.1
Mojtaba Keikha M.Sc.2

1- Department of Pediatric Cardiology, Medical School, Shahid Rajaee Cardiovascular Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- M.Sc. in Epidemiology, Medical School, Emam Hosein Hospital, Esfahan University of Medical Sciences, Child Growth and Development Research Center, Esfahan, Iran.

* Corresponding author: Emam Hosein Hospital, Emam Khomeini St., PO Box: 8195100000, Esfahan, Iran.
Tel: +98-31-33876006
E-mail: ghader_45@yahoo.co.uk

Received: 10 Jan. 2014    Accepted: 16 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Pulmonary valve stenosis (PS) is one of the most common congenital heart disease in children. Isolated pulmonary stenosis is the most common form of pulmonary stenosis. Isolated Pulmonary stenosis is responsible for 8 to 10 percent of congenital heart disease. Balloon valvuloplasty is the choice of treatment for this cardiac disease. One of the most important complications of this disease is pulmonary regurgitation in follow-up. The purpose of this study was to characterize the status of pulmonary regurgitation on follow-up after pulmonary valvuloplasty by balloon. (more…)


miRNA-21 expression analysis in 35 colorectal cancer

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):301-6

Author Affiliations:
Niusha Samadaian M.Sc.
Mohammad Hossein Modaresi M.D., Ph.D.
Maryam Mobasheri M.Sc.
Reza Ebrahim Zadeh Vesal M.Sc., Ph.D.
Seyed Mohammad Akrami M.D., Ph.D.*

Department of Medical Genetics, Tehran University of Medical Sci-ences, Tehran, Iran.

* Corresponding author: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Keshavarz Blvd., Qods St., Poursina St., Tehran, Iran.
Tel: +98-21-88953005
E-mail: akramism@tums.ac.ir

Received: 18 Apr. 2014    Accepted: 14 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Colorectal cancer is the third most common cancer in the world. Non-coding RNA especially miRNAs have important regulatory roles in cancer. miRNAs are small non coding RNA 21-23 nucleotides long which have different levels of expression between tumors and normal tissues. This study was designed to compare expression level of miRNA-21 between Iranian population colorectal cancer tissues and normal tissue. (more…)


cDesign, construction and expression of recombinant vector containing the rabies virus nucleoprotein gene

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):294-300

Author Affiliations:
Khadijeh Fanayi M.Sc.1
Mehdi Ajorloo M.Sc.2,3
Sayed Hamid Reza Mozhgani M.Sc.4
Shiva Irani Ph.D.1
Alireza Gholami Ph.D.2,5*

1- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2- Human Rabies Vaccine Laboratory, Pasteurs Production and Research Complex, Institute of Iran, Tehran, Iran.
3- Department of Virology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
4- Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
5- WHO CC For Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran.

* Corresponding author: WHO Collaborating Center for Reference and Research on Rabies, Iran Pasteur Institute, 12 Farvardin St., Tehran, Iran.
Tel: +98-21-66403496
E-mail: agholami@pasteur.ac.ir

Received: 22 May. 2014    Accepted: 29 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Rabies is an acute encephalitis that causes more than 60,000 deaths worldwide. The only way to save individuals bitten by a rabies-infected animal is the timely use of effective vaccines. Treatment with new generation vaccines is expensive. Therefore, there is a global movement towards the production of less expensive vaccines which retain and improve upon the quality and effectiveness of the vaccine. Production and evaluation of non-classical vaccines is one of the approaches taken in this regard. In this study, we describe a new eukaryotic expression system to express the nucleoprotein N gene of rabies virus which, if suitable, may be evaluated for anti-rabies vaccine production. (more…)


The effects of lactobacillus suppositories in the recovery and recurrence of bacterial vaginosis: a double-blind randomized clinical trial

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):286-93

Author Affiliations:
Soror Roozafzay M.Sc.1
Khadijeh Hekmat M.Sc.1
Kobra Shojaei Ph.D.2
Pourandokht Afshari M.Sc.1
Mohammad Bahadoram M.D.3*

1- Department of Midwifery, Re-productive Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran.
3- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran.

* Corresponding author: Esfand Ave., Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Tel: +98-611-3367543
E-mail: mohammadbahadoram@yahoo.com

Received: 12 Jun. 2014    Accepted: 30 Jun. 2014    Available online: 16 Jul. 2014

Abstract:
Background: Bacterial vaginosis (BV) is the most prevalent causes of abnormal secretion in women at fertility age. Also, Bacterial vaginosis is one of the most common diseases in women who refer to gynecology clinic. The main cause of the pathogenesis is increasing pH of vagina due to reduced number of lactobacillus and growth of anaerobic bacteria. Prevalence of BV varies between 10 to 30 percent in different societies. Amsel criteria is used as diagnostic test in BV. This interventional study was designed to assess the impact of vaginal lactobacillus suppository and metronidazole compared to metronidazole alone on the recovery and recurrence of bacterial vaginosis. (more…)


Role of the immune cells, mediators and cytokines in pathogenesis of asthma: a review article

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Original Article

Tehran Univ Med J (TUMJ) 2014 August;72(5):273-85

Author Affiliations:
Sedigheh Bahrami Mahne M.Sc.1
Seyed Alireza Mahdaviani M.D.2
Nima Rezaei M.D., Ph.D.1,3*

1- Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2- Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Research Center for Immunodeficiencies, Children’s Medical Center, Dr Qarib St., Keshavarz Blvd., Tehran, Iran.
Tel: +98-21-66929234
E-mail: Rezaei_nima@tums.ac.ir

Received: 26 Jan. 2014    Accepted: 14 May. 2014    Available online: 16 Jul. 2014

Abstract:
Asthma is a chronic inflammatory disorder of the airways, associated with airway remodeling and hyperresponsiveness. It is expressed that asthma influences about 300 million people around the world, which is estimated to increase to about 400 million by 2025. The prevalence rate is 15 to 20 percent in children and 5 to 10 percent in adults, while its trend is still increasing. Inflammation plays an important role in the pathophysiology of asthma, which involves an interaction of different types of the immune cells and mediators. It leads to a number of pathophysiology changes, including bronchial inflammation, airway obstruction, and clinical episodes such as cough, wheeze and shortness of breath. Asthma is now greatly being introduced as a heterogeneous disorder and it is pointed out to the role of T cells, including Th1, Th2, Th17, and regulatory T cells. Other immune cells, especially neutrophils, macrophages and dendritic cells, as well structural cells such as epithelial and airway smooth muscle cells also produce disease-associated cytokines in asthma. (more…)


Table of Contents >> Tehran University Medical Journal (TUMJ), Volume 72, Number 4, July 2014

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The effectiveness, side effects and acceptability of locally available brand of Clopidogrel (Osvix) as anti platelet tablet in CABG patients
Imani B, Safi-Ariyan R, Manaafi B, Karampourian A, Ghazikhanlou Sani K.

The effect of consolidation treatment with intraperitoneal carboplatin in advanced epithelial ovarian cancers
Mousavi A.S, Karimi-Zarchi M, Behtash N, Mokhtari-Gorgani M, Mehrdad N, Rouhi M, Hekmatimoghaddam S.H.

Effect of preoperative education on recovery time of laparoscopic cholecystectomy: a randomized clinical trial
Sadati L, Golchini E, Pazouki A, Jesmi F, Pishgahroudsari M.

Comparison of intracytoplasmic sperm injection outcome of oligoasthenoteratozoospermic and azoospermic men
Mehrafza M, Raoufi A, Rahimian T, Abdollahian P, Nikpouri Z, Tavakkolnia R, Golmohammadi A, Hosseini A.

Comparative study of echocardiographic right ventricular systolic function before and after angioplasty on right coronary artery
Jafari A.M, Salehi N, Kazerani H, Najafi F.

The effects of the menstrual cycle on the hemodynamic response to laryngoscopy and tracheal intubation
Hussain Khan Z, Rahimi M, Kalani P, Ghorbani B.

Predictors of single-dose methotrexate treatment failure in ectopic pregnancy
Azargoon A, Ghorbani R, Mosavi S.

The effect of anthracyclines in minimal doses on cardiac function of children under chemotherapy
Rahimi Dehgolan Sh, Kompani F, Rahimi Dehgolan Sh, Tabibian E.

Epidemiology of Tuberculosis in south-west of Iran: a brief report
Beiranvand R, Ghalavandi Sh, Delpisheh A, Sayemiri K, Salmanzadeh Sh.

Diabetes Insipidus after normal vaginal delivery: a case report
Keypour F, Naghi I.