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Post treatment thyroid dysfunction and obesity in children with acute lymphoblastic leukemia and non-Hodgkin’s lymphoma: a brief report

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Brief Report

Tehran Univ Med J (TUMJ) 2014 April;72(1):59-64

Author Affiliations:
Ali Ghasemi M.D.1
Abdollah Banihashem M.D.1
Nosrat Ghaemi M.D.2
Saghi Elmi M.D.3*
Habibollah Esmaeili Ph.D.4
Reza Erfani Sayyar M.D.5
Sam Elmi M.D.6

1- Department of Pediatric Hematology and Oncology, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Pediatric Endocrinology, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Department of Pediatrics,   Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Epidemiology and Biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Department of Anesthesiology and Intensive care, Mashhad University of Medical Sciences, Mashhad, Iran.
6- Research Center for Patient Safety and Health Quality, Mashhad University of Medical Sciences, Mashhad, Iran.

* Corresponding author: Ghareni Blv., Tohid Sq., Dr.Sheikh Pediatric Hospital,  Mashhad, Iran.
Tel: +98-511-7269021
E-mail: saghi_elmi_106@yahoo.com

Received: 04 Oct. 2013    Accepted: 20 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: In most children with Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma (NHL) who have received chemotherapy with and without radiotherapy, some late effects due to treatment may occur such as endocrinopathies. (more…)


Prevalence of HLA-B*57:01 allele in HIV-infected patients in a university hospital in Tehran

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):52-8

Author Affiliations:
Mahboobeh Haji-Abdolbaghi M.D.1
Mehrnaz Rasoolinejad M.D.1
Laden Abbasian M.D.1
Aliakbar Amir Zargar Ph.D.2
Hamid Emadi Koochak M.D.1
Pardis Moradnejad M.D.1*
Naseh Mohammadi M.D.3
Ali Pashae Zanjani M.D.1
Saeed Bayanolhagh Ph.D.4
Parisa Sadr Poor M.Sc.4

1- Iranian Research Center for HIV/AIDS, Iranian Institute for   Reduction of High-Risk Behaviors, Tehran University of Medical     Sciences, Tehran, Iran.
2- Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Vitreous and   Retina, Vitreoretinal Consultant, Razi Eye Clinic, Tehran, Iran.
4- Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical     Sciences, Tehran, Iran.

* Corresponding author: Department of Infectious Diseases, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran.
Tel: +98-21-61192811
E-mail: parmorad@gmail.com

Received: 30 Nov. 2013    Accepted: 01 Feb. 2014    Available online: 01 Mar. 2014

Abstract:
Background: Abacavir is an anti-retroviral medication used to treat HIV infected/AIDS patients and its efficacy has been proven in randomized clinical trials. The most significant adverse reaction associated with abacavir is the acute hypersensitivity phenomenon which manifests in many forms and in severe cases could result in death. Hypersensitivity reaction to abacavir has been closely linked to the presence of HLA-B*57:01 allele. Avoidance of abacavir initiation in allele-positive patients is the most effective strategy in preventing possible severe hypersensitivity reactions. Previous epidemiologic studies have made great strides toward delineating HLA-B*57:01 allele frequency in different regions of the World and the available results indicate significant discrepancy between geographical regions. Despite these efforts, no study to date has determined the allele frequency among Iranian HIV-positive patients. The aim of the present study was to determine the proportion of allele-positive patients among a group of Iranian HIV-infected patients. (more…)


Presenting features and outcome of rhino-orbital-cerebral mucormycosis in two referral center in Mashhad

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):46-51

Author Affiliations:
Ashraf Tavanaee Sani M.D.1
Abdol Majid Fata Ph.D.2
Mahnaz Arian M.D.1*

1- Department of Infectious Diseases, Imam Reza Hospital, Mashhad University of Medical  Sciences, Mashhad, Iran.
2- Department of Mycology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

* Corresponding author: Mirzakuchak khan St., Vakilabad Blvd., Mashhad, Iran.
Tel: +98-511-6063397
E-mail: arianm881@yahoo.com

Received: 14 Jun. 2013    Accepted: 29 Dec. 2013    Available online: 01 Mar. 2014

Abstract:
Background: This study was done to determine presenting features and treatment outcome of Rhino-Orbital-Cerebral Mucormycosis (ROCM).

Methods: This cross sectional study was conducted during 14 years (from 1998-2012) in two educational hospitals of Mashhad University of Medical Sciences in patients with rhino-orbital-cerebral mucormycosis. Clinical symptoms, predisposing factors, demografic parameter and treatment outcome were collected by SPSS and analyzed by cox regression model. (more…)


Adamantane and Neuraminidase resistant influenza A/H3N2 isolated in Iran from 2005 to 2013

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):40-5

Author Affiliations:
Jila Yavarian M.D., Ph.D.
Nazanin Zahra Shafiei Jandaghi Ph.D.
Farhad Rezeai Ph.D.
Talat Mokhtari Azad, DVM, MPH, Ph.D.*

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Porsina St., School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Tel: +98-21-88962343
E-mail: mokhtari@tums.ac.ir

Received: 10 Sep. 2013    Accepted: 25 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: Influenza viruses are one of the most important etiological agents of respiratory disease in humans and cause epidemics and pandemics with substantial morbidity and mortality worldwide. Vaccination and antiviral treatments are the sole and essential way for the prevention and control of influenza infection. During an influenza epidemic before the production of effective vaccine, antiviral treatments are the first step for the prevention and treatment of influenza infection. Adamantanes and neuraminidase inhibitors are influenza antiviral drugs. Because of the increase of drug resistant viruses, the aim of this study was the evaluation of the antiviral drug resistance in influenza A/H3N2 viruses from 2005-2013 in Iran. (more…)


The relationship between T CD4+ cells count and IL-17, IL-11 serum level in idiopathic thrombocytopenic purpura

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):33-9

Author Affiliations:
Nayereh Alizadeh M.D.1
Saeid Abediankenari Ph.D.2*
Ghasem Janbabaei M.D.3
Hossein Karami M.D.3
Ahad Alizadeh Ph.D.4

1- Department of Immunology, Medical student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Immunology,    Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
3- Departments of Hematology and Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4- Ph.D. Student in Biostatistics, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Immunogenetic Research center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Tel: +98-151-3247805
E-mail: abedianlab@yahoo.co.uk

Received: 08 Oct. 2013    Accepted: 25 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: Immune Thrombocytopenic Purpura (ITP) is an acquired autoimmune disorder characterized by a low platelet count; because of anti platelet auto-antibodies. ITP patients have auto antibodies against platelet antigens. T CD4+ lymphocytes are effective cells in immune system that has an important role in auto reactive antibody production and class switching. The pathophisiology and mechanism of ITP is complex and unknown. Numerous studies have difference results about role of T cells in ITP patients.  T lymphocytes have been characterized to different subsets. To further investigate about the pathogenesis of ITP, we studied the role of T CD4+ cells and cytokines attributed with platelet count. Therefore, in this research, we evaluated T CD4+ lymphocytes count and interleukin 17 (IL-17), interleukin 11 (IL-11) levels in ITP in comparison with control. (more…)


Isolation, amplification and identification of mesenchymal stem cells derived from human adipose tissue

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):27-32

Author Affiliations:
Sanambar Sadighi M.D.1
Ahad Khoshzban M.D.2
Amir Hossein Tavakoli M.D.3
Ramin Khatib Semnani M.D.4
Zahra Sobhani M.D.5
Nayer Dadashpur Majidabad M.Sc.6*

1- Department of Internal Medicine, Cancer Research Center, Tehran University of Medical Sciences,   Tehran, Iran.
2- Department of Dental Materials, School of Dentistry, Tehran University, Tehran, Iran.
3- Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of General Surgery, Islamic Azad University of Medical Sciences, Tehran, Iran.
5- Physician, Tissue Bank and Research Center, Tehran, Iran.
6- M.Sc., Cellular and Molecular Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

* Corresponding author: Dept. of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Tel: +98-412-7236078
E-mail: n_dadashpour@yahoo.com

Received: 01 Nov. 2013    Accepted: 15 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: Currently, autologous and allogeneic adipose tissues represent a ubiquitous source of material for fat reconstructive therapies. However, these approaches are limited, and often accompanied by a 40-60% reduction in graft volume following transplantation, limited proliferative capacity of mature adipocytes for ex vivo expansion, and extensive adipocyte damage encountered when harvested with conventional liposuction techniques. Recently, cell-based approaches utilizing adipogenic progenitor cells for fat tissue engineering have been developed and were reported to promote both short-term in vivo adipogenesis and to repair defect sites. The aim of this study was to isolate stem cells from fat tissue than examine the growth of stem cells by invitro tests. (more…)


Plasma levels of osteocalcin and retinol binding protein-4 in patients with medullary thyroid carcinoma

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):22-6

Author Affiliations:
Jabar Lotfi M.Sc.1
Mohammad Taghikhani Ph.D.1*
Marjan Zarif Yeganeh M.Sc.2
Sara Sheikholeslami M.Sc.2
Mehdi Hedayati Ph.D.2

1- Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2- Cellular and Molecular Endocrine Science, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

* Corresponding author: Dept. of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran, Iran.
Tel: +98-21-82884512
E-mail: taghi_mo@modares.ac.ir

Received: 05 Aug. 2013    Accepted: 29 Dec. 2013    Available online: 01 Mar. 2014

Abstract:
Background: Thyroid carcinoma is the most frequent malignant tumor of the endocrine system in human body and accounts for nearly 1% of all cancers. Medullary thyroid carcinoma is the third frequent of thyroid cancer and accounts about 5-8% of thyroid cancer. Osteocalcin, known as a Bone Gamma-carboxyglutamic Acid-containing Protein (BGLAP), is the most non collagenous protein. Retinol binding proteins are the family of proteins that have diverse actions but mainly transport retinol in human body. In this study to evaluate effect of existence medullary thyroid carcinoma on metabolism of bone and adipose tissue, plasma level of two mentioned proteins had analyzed. (more…)


Correlation of liver enzymes and sonographic findings with pulsatile index of middle cerebral and basilar arteries in nonalcoholic fatty liver

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):15-21

Author Affiliations:
Gholamreza Rezamand M.D.1
Mojdeh Ghabaee M.D.2*
Naser Ebrahimi Daryani M.D.3
Hoda Ghadami M.D.4

1- Internal Medicine Resident, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Neurology, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical     Sciences, Tehran, Iran.
3- Department of Gastroenterology and Hepatology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
4- Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.

* Corresponding author: Iranian Center of Neurological Research, Imam khomeini Hospital Complex, Keshavarz Blvd., Tehran, Iran.
Tel: +98-21-66912274(281)
E-mail: mojdeh.ghabaee@gmail.com

Received: 18 Aug. 2013    Accepted: 11 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: Nonalcoholic Fatty Liver Disease (NAFLD) is one of the most wide-spread human diseases that can impair liver function and sometimes progresses to cirrhosis. Recently NAFLD has been identified as an independent risk factor for cardiovascular disease. The aim of this study was to investigate the correlation of fatty liver disease and its sonographic severity on the resistance of the intracranial arteries. (more…)


CAM visual stimulation with conventional method of occlusion treatment in amblyopia: a randomized clinical trial

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):7-14

Author Affiliations:
Ali Reza Jafari M.Sc.1
Ali Akbar Shafiee M.Sc.2
Ali Mirzajani Ph.D.3*
Peyman Jamali M.D., MPH4

1- Research Center of Basir Eye Clinic, Tehran, Iran.
2- Private Practice, Shafiee  Optometry Clinic, Tehran, Iran.
3- Department of Optometry, Rehabilitation Research Center, Rehab. School, Iran University of Medical Sciences, Tehran, Iran.
4- Shahrood Welfare Organization, Prevention Department, Shahrood, Iran.

* Corresponding author: Optometry Department of Rehabilitation Sciences School of Iran University of Medical Sciences, Shahid Shah Nazari St, Mirdamad Blvd., Tehran, Iran.
Tel: +98-21-22269609
E-mail: mirzajani.a@Iums.ac.ir

Received: 02 Oct. 2013    Accepted: 27 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: The application of CAM visual stimulation returns to the date of more than fifty years ago. However, the reports of previous studies in this field vary from no effect to significant effects of this method in amblyopia treatment. The purpose of this study was to determine the effect of CAM visual stimulation along with conventional occlusion therapy in anisometropic amblyopic children. (more…)


Reciprocal effects of cadmium and pH on the intestinal absorption of fatty acids in rat

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Original Article

Tehran Univ Med J (TUMJ) 2014 April;72(1):1-6

Author Affiliations:
Amirnader Emami Razavi Ph.D.1
Gholam Basati Ph.D.2*
Soheila Abdi Ph.D.3

1- Iran National Tumor Bank, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Clinical Biochemistry, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.
3- Department of Physics, Safadasht Branch, Islamic Azad University, Safadasht, Iran.

* Corresponding author: Publications and Scientific Journals Office, Ilam University of Medical Sciences, Banganjab St., Ilam, Iran.
Tel: +98-841-2227147
E-mail: basati-gh@medilam.ac.ir

Received: 11 Nov. 2013    Accepted: 11 Jan. 2014    Available online: 01 Mar. 2014

Abstract:
Background: The intestinal absorption of fatty acids may take place through simple diffusion as well as through protein carrier mediated transport, although the relative importance of each pathway is dependent on the ambient condition of entrocytes. Cadmium ion influences the absorption of fatty acids in entrocytes. However, the effect of cadmium ion on the absorption of fatty acids in different pH values has not been evaluated yet. Especially, the luminal pH of small intestine has an essential role in the absorption of fatty acids. In the present study we aimed to evaluate reciprocal effects of cadmium ion and pH of intestine lumen on the absorption of fatty acids in rat model. (more…)


Table of Contents >> Tehran University Medical Journal (TUMJ), Volume 71, Number 12, March 2014

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Microsatellite instability detection using BAT-25 and BAT-26 by Real Time PCR and HPLC in colorectal cancer
Rismanchi M, Mokarram P, Alizadeh Naeeni M, Paryan M, Honardar Z, Kavousipour S, Alipour A.

Changes in IL-6 and interferon gamma levels in induced varicocele in premature rats
Habibi B, Seifi B, Sadeghipour Roudsari H, Amir Zargar A.A, Noori Mugahi S.M.H.

Central effects of synthesized dihydropyridine derivatives and nifedipine on systolic blood pressure and heart rate of rats
Bakhtiarian A, Ostadhadi S, Jorjani M, Hashempour S, Oryan Sh, Nikoui V.

Celecoxib versus prednisolone in medication overuse headache withdrawal treatment: double blind randomized clinical trial
Toghae M, Ghini M.R, Paknejad S.M.H, Taghvaii Zahmat Kesh E, Ramim T.

Vitamin C in prevention of atrial fibrillation after coronary artery bypass graft: double blind randomized clinical trial
Sarzaeem M, Shayan N.

Vitamin A, D and zinc serum levels in children with and without acute respiratory tract infection in two university hospitals
Javadi-Nia Sh, Noorbakhsh S, Izadi A, Shokrollahi M.R, Asgarian R, Tabatabaei A.

Prophylactic dialysis in non-dialysis-dependent patients with renal failure after CABG
Borji R, Khatami M.R, Abbasi M.R, Meysamie A, Barkhordari Kh, Ayatollah Esfahani F, Pashang M, Ghadirian L.

Outcomes of vaginal delivery and cesarean in Mashhad Ghaem University Hospital
Boskabadi H, Zakerihamidi M, Bagheri F.

Comparative study on the effect of fish-oil derived docosahexaenoic and ecosapantaenoic acid on proliferation of colorectal cancer cell line: a breif report
Ahangar P, Sam M.R, Nejati V.

Incomplete molar pregnancy with live coexisting fetus: a case report
Pourali L, Ayati S, Vahidroodsari F, Javanmard M, Poursadrollah F.